禽白血病/肉瘤病毒肿瘤基因及其与致肿瘤机制的关系

畜牧兽医学报 ›› 2012, Vol. 43 ›› Issue (3): 336-342.

禽白血病/肉瘤病毒肿瘤基因及其与致肿瘤机制的关系

陈浩，王一新，赵鹏，李建亮，李德庆，崔治中*

山东农业大学动物医学院/山东省畜禽疫病防制工程技术研究中心，泰安 271018

收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2012-03-28 发布日期:2012-03-28
通讯作者: 崔治中

The Relationship between Oncogene and Oncogenesis Mechanism of Avian Leukosis/Sarcoma Viruses

CHEN Hao， WANG Yixin， ZHAO Peng， LI Jianliang， LI Deqing， CUI Zhizhong*

College of Veterinary Medicine， Shandong Agricultural University/Shandong Engineering Research Center for Animal Disease Control and Prevention， Tai’an 271018， China

Received:1900-01-01 Revised:1900-01-01 Online:2012-03-28 Published:2012-03-28
Contact: CUI Zhizhong*

摘要/Abstract

摘要： 根据致瘤机制的差异，禽白血病/肉瘤病毒可以分为两大类，其差异主要在于所表达肿瘤基因的不同。慢性转化型病毒通过插入启动机制间接激活细胞原癌基因，肿瘤形成速度缓慢；急性转化型病毒则是直接转录表达病毒自身基因组中的病毒肿瘤基因，从而诱导肿瘤的快速形成。作者拟对禽白血病/肉瘤病毒肿瘤基因及其与致肿瘤机制的关系进行综述。

关键词: 细胞原癌基因, 病毒肿瘤基因, 插入启动, 急性转化型病毒

Abstract: Avian leukosis/sarcoma viruses were divided into two categories according to the difference of the activated oncogenes. Nonacute transforming virus can cause tumors by insertional activation of cellular protooncogene with a long latency, while acute transforming virus can induce a fast tumorigenesis through direct transcription of viral oncogene. This paper will review the relationship between the oncogenesis mechanism and oncogenes.

Key words: cellular protooncogene, viral oncogene, insertional activation, acute transforming virus

陈浩;王一新;赵鹏;李建亮;李德庆;崔治中. 禽白血病/肉瘤病毒肿瘤基因及其与致肿瘤机制的关系[J]. 畜牧兽医学报, 2012, 43(3): 336-342.

CHEN Hao;WANG Yixin;ZHAO Peng;LI Jianliang;LI Deqing;CUI Zhizhong. The Relationship between Oncogene and Oncogenesis Mechanism of Avian Leukosis/Sarcoma Viruses[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2012, 43(3): 336-342.