Abstract: The aim of this study was to explore the differential expression of cadherin 1 (CDH1) in the growth plate of broiler chickens with tibial dyschondroplasia (TD) induced by thiram at the early stage. Chickens were dissected and growth plates were fixed in 4% paraform respectively in 4 ℃ at days 1, 2 and 6. RNA was extracted from the growth plates of control and thiramfed chickens. Then differential expression of CDH1 was identified by realtime PCR and immunohistology. The results showed that expression of CDH1 was upregulated on the growth plate of thiramdiet fed group. CDH1 protein synthesis mainly lied in cytoplasm of the prehypertrophic and hypertrophic chondrocyte in control or TD growth plates. No expression was discovered at proliferative zone and low expression was detected at calcification zone. Remarkably increased CDH1 was detected in TD growth plates at days 1, 2 and 6 after feeding thiram diet, which mirrored with their mRNA differential expression, and highly increased CDH1 staining was clearly seen at days 2 and 6 respectively. It was suggested that CDH1 was associated with cell adhesion, blood vessel invasion and it also regulated Wnt/βcat signal transmission with other regulator among endochondral bone formation.