Abstract: Porcine dendritic cells(DCs) from fortydayold SPF piglets inoculated oralnasally with porcine circovirus type 2 （PCV2） B1 strain were collected at different days post inoculation (DPI). Realtime FQPCR was used to detect the kinetics of mRNAs of IL10, TNFα, IFNα, IL8, chemokine CC motif receptor1 (CCR1) and CCR5 from skin DCs. The results showed that the transcriptions of proinflammatory cytokines mRNA decreased with significant levels of IFNα at 3DPI, TNFα and IL10 mRNA were increased significantly at 7DPI(P<0.05). The transcriptions of chemokine IL8 mRNA decreased with almost significant levels. MCP1 mRNAs were down at 3DPI and 14DPI, up at 7DPI, while the transcriptions of MIP1β mRNA were up at 3DPI and 7DPI, and back to the normal levels at 14DPI. The transcriptions of CCR1 and CCR5 were up at 3DPI, 7DPI and 14DPI, with significant increase at 7DPI (P<0.05). Taken together, PCV2 could significantly weaken the inflammatory reactions of porcine skin DC, and make its immune response out of control. These will affect the humoral immunity and cellular immunity of the animals.