畜牧兽医学报 ›› 2021, Vol. 52 ›› Issue (10): 2721-2739.doi: 10.11843/j.issn.0366-6964.2021.010.004
杜雪儿, 王菁, 姚军虎, 曹阳春*
收稿日期:
2021-04-12
出版日期:
2021-10-23
发布日期:
2021-10-27
通讯作者:
曹阳春,主要从事反刍动物营养研究,E-mail:caoyangchun@126.com
作者简介:
杜雪儿(1998-),女,陕西榆林人,硕士生,主要从事反刍动物营养研究,E-mail:1713371921@qq.com
基金资助:
DU Xue'er, WANG Jing, YAO Junhu, CAO Yangchun*
Received:
2021-04-12
Online:
2021-10-23
Published:
2021-10-27
摘要: 胆汁酸作为胆汁的重要成分,由肝以胆固醇为原料进行合成,能在外源食物及相关激素的刺激下与胆汁一同被排入消化道内,具有脂肪乳化、促进肠道吸收脂质、调节肝肠功能、增加能量消耗、改善胰岛素敏感性等作用,一般可通过经典途径和替代途径两种方式进行合成。肠肝循环能将从头合成的胆汁酸重新回收约95%,仅剩余5%会流失,经替代途径进行再补充,从而保障了胆汁酸池的动态平衡,因此,肠肝循环在调节胆汁酸稳态等方面具有重要作用。近年来,随着研究的深入,胆汁酸的代谢与运输机制逐渐明确,参与肠肝循环的转运蛋白功能也更加清晰,其中,法尼酯X受体(FXR)作为重要的核因子能通过与小异二聚体受体(SHP)、视黄酸受体α(RARα)等,联合成纤维细胞生长因子15/19(FGF15/19)对胆汁酸转运蛋白的表达量进行调控,进而影响胆汁酸稳态。本文将对胆汁酸肠肝循环过程中涉及到的重要转运蛋白及FXR对其的调节机制进行阐述,为今后进一步探究胆汁酸功能提供一定的理论基础。
中图分类号:
杜雪儿, 王菁, 姚军虎, 曹阳春. 胆汁酸肠肝循环转运蛋白及FXR对其的调控机制[J]. 畜牧兽医学报, 2021, 52(10): 2721-2739.
DU Xue'er, WANG Jing, YAO Junhu, CAO Yangchun. Bile Acid Enterohepatic Circulation Transporter and Its Regulatory Mechanism by FXR[J]. Acta Veterinaria et Zootechnica Sinica, 2021, 52(10): 2721-2739.
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