Abstract: To investigate the genetic variability of Hal, RN and FTO genes related to meat quality among foreign and Chinese pig breeds, the polymorphism of these genes in four pig breeds including Duroc, Landrace, Large Yorkshire and Jinhua pig were detected by PCRRFLP, respectively. The genetic variation of g.276G>T and c.594C>G in FTO gene were analyzed. The results showed as follows: (1) For Hal gene, HalNHaln genotype was detected and its frequency was 0.166, but no HalnHaln genotype was detected in Duroc pig. Only HalNHalN genotype was found in Landrace, Large Yorkshire and Jinhua pig. (2) For RN gene, only rn/rn genotype was detected in four pig breeds. (3) At g.276G>T site in FTO gene, three breeds including Duroc, Landrace and Large Yorkshire pig had polymorphism, but Jinhua pig had no polymorphism. At c.594C>G site in FTO gene, all the breeds had polymorphism. However, higher CC genotype frequency was found in Duroc, Landrace and Large Yorkshire pig, but in Jinhua pig GG genotype frequency was higher. These results indicate that higher frequency of HalNHaln genotype has existed in some pig breeds because Hal gene show benefits and defects for pig production. Moreover, FTO gene could be regarded as a candidate gene affecting meat quality in special pig populations according to its known functions and the previous reports. This result show that the genotypes of FTO are very significantly different between the foreign breeds and Chinese indigenous breeds, which provide some data for further study on the molecular mechanism of meat quality of different pig breeds.