Abstract: The aim of this study was to study the polymorphisms on exons of IRS1 gene and their association with several body measurements and meat quality traits in Qinchuan cattle. The polymorphisms on exons of bovine IRS1 gene was detected by using PCRSSCP and DNA sequencing technology. 384 Qinchuan cattle with 18 to 24 months old were selected and the polymorphisms of bovine IRS1 gene and their associations with body measurements and meat quality traits were analyzed. Two SNPs on exons of bovine IRS1 gene were identified: B1 site g. +2346 G>A, Glu>Glu; B2 site: g. +2394G>A, Leu>Leu. Two genotypes at each sites( B1 site: CC and CD；B2 site：AA and AB) were identified and homozygote DD and BB were not detected in the study. The result of χ2 test showed that B1 site was in agreement with the HardyWeinberg equilibrium (P>0.05), B2 site was significantly deviated from HardyWeinberg equilibrium (P<0.01). At B1 site, genotype CC was dominant genotype, C was preponderant allele, the site belonged to intermediate genetic diversity. At B2 site, genotype AA was dominant genotype, A was preponderant allele, the site belonged to low genetic diversity. The result of association analysis demonstrated, at B1 site, individuals with different genotypes had significant differences in body length, hip width, chest circumference and loineye area (P<0.05), at B2 site, individuals with different genotypes had significant differences in hip width, chest depth and backfat thickness (P<0.05). Furthermore, haplotype analysis showed that body measurement traits of individuals with combined genotype ABCD were significantly higher than those of the other kinds of combinations except on backfat thickness and intramuscular fatty content. The effect of multiloci combinations on individuals were higher than those of singlemarker loci. As the result showed, IRS1 gene had a significant effect on body measurement and carcass traits in Qinchuan cattle. Hence, it could be took as a candidate gene for selecting new breed of Qinchuan cattle and the ABCD genotype maybe the best one for the Qinchuan cattle breeding.