Abstract: This experiment was conducted to investigate the effects of Alanyglutamine (Ala-Gln) on antioxidant ability and protecting intestine of early weanling piglets. 48 piglets of weanling at 35 days (half male, half female), reproduced by Yunnan Saba sows with similar body weight, parity, milk yields and litter size, were designed randomly to 4 groups, each has 3 repeats with 4 piglets per repeat. Group A (control) was fed the basal diet, and experimental diets with adding 0.15%, 0.30% and 0.45% for group B, C and D, respectively. The duration of experiments was from 35 to 60 days. The results indicated that growth performance of piglets can be improved with Ala-Gln supplementation of 0.15％, 0.30％ and 0.45%, respectively. With the increase of dietary Ala-Gln supplementation，body weight and daily feed intake for piglets were increased (P<0.05) and feed:gain was decreased as a quadratic function (P<0.05). At the 49th day，the serum T-AOC and SOD concentrations were increased (P<0.05)，and the serum MDA contents was decreased as quadratic equation (P<0.01). The results of intestinal morphology determination showed that the length of duodenum and ileum villus for piglets increased as quadratic equation (P<0.01),and length of jejunum villus increased as a quadratic function (P<0.05), duodenal and jejunal crypt depth reduced as the quadratic function (P<0.05), ratio (V / C) of duodenum, jejunum and ileum villus length to crypt depth can be improved as the quadratic manner (P<0.01). It was concluded that the growth performance and antioxidant ability of Saba weanling piglets can be improved, and intestine structures and functional development can be protected with adding dietary Ala-Gln.