外泌体在机体抗结核分枝杆菌感染中的作用及其应用

doi:10.11843/j.issn.0366-6964.2018.09.001

Abstract

Abstract:

Tuberculosis (TB) is a severe pulmonary disease and a public health burden caused by the infection of Mycobacterium tuberculosis (Mtb). Every year, millions of people die of TB worldwide. Unfortunately, so far, little breakthrough progress has been made in the prevention and treatment of TB. Exosomes are small membrane vesicles that can be secreted by most cells in the body; it plays important roles in intercellular communication and other physiological processes by shuttling various molecules from donor to recipient cells. Recent studies have found that exosomes also play important roles in the host defense against Mtb infection. In this review, we summarized the role of exosomes in anti-Mtb infection and its application.

Key words: tuberculosis, Mycobacterium tuberculosis, exosomes, diagnosis, vaccine

CLC Number:

XU Zhao-kun, LI Wu, WANG Yu-jiong. The Roles and Applications of Exosomes in the Host Defense against Mycobacterium tuberculosis Infection[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2018, 49(9): 1803-1809.

References

[1] WHO. Global tuberculosis report 2016[R]. Geneva:WHO, 2016.
[2] THÉRY C. Exosomes:secreted vesicles and intercellular communications[J]. F1000 Biol Rep, 2011, 3:15.
[3] KRUH-GARCIA N A, SCHOREY J S, DOBOS K M. Exosomes:new tuberculosis biomarkers-prospects from the bench to the clinic[R]. Rijeka:INTECH Open Access Publisher, 2012.
[4] RAPOSO G, STOORVOGEL W. Extracellular vesicles:exosomes, microvesicles, and friends[J]. J Cell Biol, 2013, 200(4):373-383.
[5] LIN J, LI J, HUANG B, et al. Exosomes:novel biomarkers for clinical diagnosis[J]. Sci World J, 2015, 2015:657086.
[6] TICKNER J A, URQUHART A J, STEPHENSON S A, et al. Functions and therapeutic roles of exosomes in cancer[J]. Front Oncol, 2014, 4:127.
[7] ALIPOOR S D, MORTAZ E, TABARSI P, et al. Bovis Bacillus Calmette-Guerin (BCG) infection induces exosomal miRNA release by human macrophages[J]. J Transl Med, 2017, 15:105.
[8] MORTAZ E, ALIPOOR S D, TABARSI P, et al. The analysis of exosomal micro-RNAs in peripheral blood mononuclear cell-derived macrophages after infection with bacillus Calmette-Guérin by RNA sequencing[J]. Int J Mycobacteriol, 2016, 5(Suppl 1):S184-S185.
[9] LEE J, KIM S H, CHOI D S, et al. Proteomic analysis of extracellular vesicles derived from Mycobacterium tuberculosis[J]. Proteomics, 2015, 15(19):3331-3337.
[10] SUN T, KALIONIS B, LV G Y, et al. Role of exosomal noncoding RNAs in lung carcinogenesis[J]. Bio Med Res Int, 2015, 2015:125807.
[11] ELDH M. Exosomes and exosomal RNA-a way of cell-to-cell communication[D]. Gothenburg:University of Gothenburg, 2013.
[12] KOUREMBANAS S. Exosomes:vehicles of intercellular signaling, biomarkers, and vectors of cell therapy[J]. Annu Rev Physiol, 2015, 77:13-27.
[13] CHENG Y, SCHOREY J S. Exosomes carrying mycobacterial antigens can protect mice against Mycobacterium tuberculosis infection[J]. Eur J Immunol, 2013, 43(12):3279-3290.
[14] XU S, COOPER A, STURGILL-KOSZYCKI S, et al. Intracellular trafficking in Mycobacterium tuberculosis and Mycobacterium avium-infected macrophages[J]. J Immunol, 1994, 153(6):2568-2578.
[15] WANG J J, CHEN C, XIE P F, et al. Proteomic analysis and immune properties of exosomes released by macrophages infected with Mycobacterium avium[J]. Microbes Infect, 2014, 16(4):283-291.
[16] RAMACHANDRA L, QU Y, WANG Y, et al. Mycobacterium tuberculosis synergizes with ATP to induce release of microvesicles and exosomes containing major histocompatibility complex class Ⅱ molecules capable of antigen presentation[J]. Infect Immun, 2010, 78(12):5116-5125.
[17] ANAND P K, ANAND E, BLECK C K E, et al. Exosomal Hsp70 induces a pro-inflammatory response to foreign particles including mycobacteria[J]. PLoS One, 2010, 5(4):e10136.
[18] SCHOREY J S, BHATNAGAR S. Exosome function:from tumor immunology to pathogen biology[J]. Traffic, 2008, 9(6):871-881.
[19] WANG J J, YAO Y L, XIONG J, et al. Evaluation of the inflammatory response in macrophages stimulated with exosomes secreted by Mycobacterium avium-infected macrophages[J]. BioMed Res Int, 2015, 2015:658421.
[20] SMITH V L, CHENG Y, BRYANT B R, et al. Exosomes function in antigen presentation during an in vivo Mycobacterium tuberculosis infection[J]. Sci Rep, 2017, 7:43578.
[21] GIRI P K, KRUH N A, DOBOS K M, et al. Proteomic analysis identifies highly antigenic proteins in exosomes from M. tuberculosis-infected and culture filtrate protein-treated macrophages[J]. Proteomics, 2010, 10(17):3190-3202.
[22] KRUH-GARCIA N A, WOLFE L M, DOBOS K M. Deciphering the role of exosomes in tuberculosis[J]. Tuberculosis (Edinb), 2015, 95(1):26-30.
[23] SINGH P P, LEMAIRE C, TAN J C, et al. Exosomes released from M. tuberculosis infected cells can suppress IFN-γ mediated activation of naïve macrophages[J]. PLoS One, 2011, 6(4):e18564.
[24] MORTAZ E, ALIPOOR S D, TABARSI P, et al. The analysis of exosomal micro-RNAs in peripheral blood mononuclear cell-derived macrophages after infection with bacillus Calmette-Guérin by RNA sequencing[J]. Int J Mycobacteriol, 2016, 5(S1):S184-S185.
[25] SINGH P P, LI L, SCHOREY J S. Exosomal RNA from Mycobacterium tuberculosis-infected cells is functional in recipient macrophages[J]. Traffic, 2015, 16(6):555-571.
[26] MARTIN C J, CAREY A F, FORTUNE S M. A bug's life in the granuloma[J]. Semin Immunopathol, 2016, 38(2):213-220.
[27] WALLIS R S, PAI M, MENZIES D, et al. Biomarkers and diagnostics for tuberculosis:progress, needs, and translation into practice[J]. Lancet, 2010, 375(9729):1920-1937.
[28] MAERTZDORF J, KAUFMANN S H E, WEINER Ⅲ J. Toward a unified biosignature for tuberculosis[J]. Cold Spring Harb Perspect Med, 2014, 5(1):a018531.
[29] UEBERBERG B, KOHNS M, MAYATEPEK E, et al. Are microRNAs suitable biomarkers of immunity to tuberculosis?[J]. Mol Cell Pediatr, 2014, 1:8.
[30] WALZL G, HAKS M C, JOOSTEN S A, et al. Clinical immunology and multiplex biomarkers of human tuberculosis[J]. Cold Spring Harb Perspect Med, 2014, 5(4):a018515.
[31] STAALS R H J, PRUIJN G J M. The human exosome and disease[M]//JENSEN T H. RNA Exosome. New York, NY:Springer, 2010:132-142.
[32] BEATTY W L, RHOADES E R, ULLRICH H J, et al. Trafficking and release of mycobacterial lipids from infected macrophages[J]. Traffic, 2000, 1(3):235-247.
[33] SIMPSON R J, LIM J W, MORITZ R L, et al. Exosomes:proteomic insights and diagnostic potential[J]. Expert Rev Proteomics, 2009, 6(3):267-283.
[34] FUJITA Y, KOSAKA N, ARAYA J, et al. Extracellular vesicles in lung microenvironment and pathogenesis[J]. Trends Mol Med, 2015, 21(9):533-542.
[35] LÄSSER C. Exosomal RNA as biomarkers and the therapeutic potential of exosome vectors[J]. Expert Opin Biol Ther, 2012, 12(Suppl 1):S189-S197.
[36] SCHOREY J S, CHENG Y, SINGH P P, et al. Exosomes and other extracellular vesicles in host-pathogen interactions[J]. EMBO Rep, 2015, 16(1):24-43.
[37] LIN J, WANG Y, ZOU Y Q, et al. Differential miRNA expression in pleural effusions derived from extracellular vesicles of patients with lung cancer, pulmonary tuberculosis, or pneumonia[J]. Tumor Biol, 2016, 37(12):15835-15845.
[38] LV L N, LI C D, ZHANG X L, et al. RNA profiling analysis of the serum exosomes derived from patients with active and latent mycobacterium tuberculosis infection[J]. Front Microbiol, 2017, 8:1051.
[39] WANG Y, XU Y M, ZOU Y Q, et al. Identification of differential expressed PE exosomal miRNA in lung adenocarcinoma, tuberculosis, and other benign lesions[J]. Medicine (Baltimore), 2017, 96(44):e8361.
[40] KRUH-GARCIA N A, WOLFE L M, CHAISSON L H, et al. Detection of Mycobacterium tuberculosis peptides in the exosomes of patients with active and latent M. tuberculosis infection using MRM-MS[J]. PLoS One, 2014, 9(7):e103811.
[41] MEHAFFY C, DOBOS K M, NAHID P, et al. Second generation multiple reaction monitoring assays for enhanced detection of ultra-low abundance Mycobacterium tuberculosis peptides in human serum[J]. Clin Proteomics, 2017, 14:21.
[42] DIAZ G, WOLFE L M, KRUH-GARCIA N A, et al. Changes in the membrane-associated proteins of exosomes released from human macrophages after Mycobacterium tuberculosis infection[J]. Sci Rep, 2016, 6:37975.
[43] QAZI K R, TORREGROSA PAREDES P, DAHLBERG B, et al. Proinflammatory exosomes in bronchoalveolar lavage fluid of patients with sarcoidosis[J]. Thorax, 2010, 65(11):1016-1024.
[44] SCHOREY J S, DOBOS K M. Exosomes and diagnostic biomarkers:USA, 9255924[P]. 2016-02-09.
[45] MITTELBRUNN M, GUTIÉRREZ-VÁZQUEZ C, VILLARROYA-BELTRI C, et al. Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells[J]. Nat Commun, 2011, 2:282.
[46] JOHNSTONE R M. Exosomes biological significance:a concise review[J]. Blood Cells Mol Dis, 2006, 36(2):315-321.
[47] DELCAYRE A, SHU H, LE PECQ J B. Dendritic cell-derived exosomes in cancer immunotherapy:exploiting nature's antigen delivery pathway[J]. Expert Rev Anticancer Ther, 2005, 5(3):537-547.
[48] DE TORO J, HERSCHLIK L, WALDNER C, et al. Emerging roles of exosomes in normal and pathological conditions:new insights for diagnosis and therapeutic applications[J]. Front Immunol, 2015, 6:203.
[49] KOYAMA Y, ITO T, HASEGAWA A, et al. Exosomes derived from tumor cells genetically modified to express Mycobacterium tuberculosis antigen:a novel vaccine for cancer therapy[J]. Biotechnol Lett, 2016, 38(11):1857-1866.
[50] CHENG Y, SCHOREY J S. Targeting soluble proteins to exosomes using a ubiquitin tag[J]. Biotechnol Bioeng, 2016, 113(6):1315-1324.
[51] SMITH V L, JACKSON L, SCHOREY J S. Ubiquitination as a mechanism to transport soluble mycobacterial and eukaryotic proteins to exosomes[J]. J Immunol, 2015, 195(6):2722-2730.
[52] WU S C, YANG J C S, RAU C S, et al. Profiling circulating microRNA expression in experimental sepsis using cecal ligation and puncture[J]. PLoS One, 2013, 8(10):e77936.
[53] CANITANO A, VENTURI G, BORGHI M, et al. Exosomes released in vitro from Epstein-Barr virus (EBV)-infected cells contain EBV-encoded latent phase mRNAs[J]. Cancer Lett, 2013, 337(2):193-199.
[54] NARAYANAN A, IORDANSKIY S, DAS R, et al. Exosomes derived from HIV-1-infected cells contain trans-activation response element RNA[J]. J Biol Chem, 2013, 288(27):20014-20033.

The Roles and Applications of Exosomes in the Host Defense against Mycobacterium tuberculosis Infection

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