基于转录组学筛选与哺乳动物睾丸发育相关基因及调控网络的研究进展

doi:10.11843/j.issn.0366-6964.2018.09.002

Abstract

Abstract:

Testis maturation and development are a prerequisite for spermatogenesis and effective reproduction in mammals, the process of maturation is extremely complex, which was affected by multiple factors, especially genetic factors. Testis development process was strictly regulated by lots of protein-coding genes, while growing evidences showed that non-coding RNAs(miRNAs, lncRNAs and piRNAs)also played an important roles in testicular development and spermatogenesis. In recent years, the study of transcriptome based on mRNA, miRNA, lncRNA and piRNA have been successfully applied in exploring molecular mechanism of mammalian testicular development and spermatogenesis, and have made great progress. In this review, we summarized the current status of testis development research in mammals from the aspect of testicular developmental-related genes, miRNAs, lncRNAs and piRNA in order to provide reference and theoretical basis for understanding global genome expression change in testicular development and better guide in animal breeding in the livestock industry.

Key words: mRNA, miRNA, lncRNA, piRNA, testicular development, spermatogenesis

CLC Number:

S814

SUN Wu, LUO Jing, LI Fa-di, LI Wan-hong, YUE Xiang-peng. Progress of Screening Genes and Regulating Network Related to Testis Development in Mammals Based on Transcriptomics[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2018, 49(9): 1810-1817.

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Progress of Screening Genes and Regulating Network Related to Testis Development in Mammals Based on Transcriptomics

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