白藜芦醇对高脂诱导大鼠生长、血脂代谢及抗氧化力的影响

doi:10.11843/j.issn.0366-6964.2017.11.024

Abstract

Abstract:

This study was conducted to investigate the effects of resveratrol (RES) on the growth, serum biochemical indexes, antioxidant capacity and intestinal morphology in rats fed with high fat diet. Twenty-five male Sprague-Dawley rats of 6 weeks of age were randomly divided into 5 groups with 5 replicates of 1 rat each. The rats in the 5 groups were respectively fed a basal diet, basal diet + low dose RES (30 mg·(kg BW)^-1), high fat diet, high fat diet+low dose RES (30 mg·(kg BW)^-1), high fat diet+high dose RES(60 mg·(kg BW)^-1). The trial lasted for 4 weeks. The results showed as follows:1)Compared with the basal diet group, the body weight of the rats in the high fat diet group significantly increased (P<0.05), but there was no significant difference between the basal diet and basal diet+low dose RES groups (P>0.05). Compared to the high fat diet group, low or high dose resveratrol supplemented in high fat diet decreased the body weight of the rats, but the changes were not significant(P>0.05), while the addition of low-dose resveratrol in high fat diet significantly reduced the feed intake (P<0.05). 2)Compared with the basal diet group, the levels of urea nitrogen and the activity of fatty acid synthase(FAS) in the serum of rats in the high fat diet group were significantly decreased (P<0.05);Compared with the high fat diet group, the addition of high dose of resveratrol in the high fat diet significantly reduced the levels of triglyceride (TG) and non esterified fatty acid (NEFA) (P<0.05), and increased the content of high density lipoprotein (HDL) (P<0.05). 3)The addition of low-dose resveratrol in basal diet significantly decreased the activity of GSH-Px in rat serum (P<0.05). Compared with the high fat diet group, the addition of low or high dose of resveratrol in the high fat diet significantly reduced the MDA concentration in serum (P<0.05), increased T-SOD activity and T-AOC (P<0.05). 4)Compared with the high fat diet group, the addition of low or high dose of resveratrol in the high fat diet significantly increased the crypt depth of jejunum (P<0.05), and had a tendency to increase the villus height of jejunum (P<0.1). In conclusion, resveratrol can effectively alleviate oxidative stress, promote growth and nutrients utilization, improve blood lipid metabolism and enhance antioxidant capacity of rats with high fat diet, while have no significant effect on the protection of intestinal morphology and structure.

CLC Number:

S816.7

DING Ya-nan, ZHAO Yue-xiang, WANG Ling-xia, HAN Jin-feng, SONG Ze-he, HU Gui-li, LI Guan-ya, FAN Zhi-yong. Effects of Resveratrol on the Growth, Blood Lipid Metabolism and Antioxidant Capacity of Rats Fed with High Fat Diet[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2017, 48(11): 2216-2224.

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Effects of Resveratrol on the Growth, Blood Lipid Metabolism and Antioxidant Capacity of Rats Fed with High Fat Diet

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