哺乳动物妊娠中miRNA的作用

doi:10.11843/j.issn.0366-6964.2018.11.002

畜牧兽医学报 ›› 2018, Vol. 49 ›› Issue (11): 2310-2316.doi: 10.11843/j.issn.0366-6964.2018.11.002

哺乳动物妊娠中miRNA的作用

韩志强^1,2, 宋兴超¹, 王海军³, 贾赟⁴, 赵家平¹, 赵全民², 邢秀梅¹, 徐超^1*

1. 中国农业科学院特产研究所, 农业部特种经济动物遗传育种与繁殖重点实验室, 吉林省特种经济动物分子生物学省部共建国家重点实验室, 长春 130112;
2. 吉林农业大学, 长春 130118;
3. 吉林省野生动物救护繁育中心, 长春 130119;
4. 辽宁出入境检验检疫局技术中心, 大连 116001

收稿日期:2018-03-05 出版日期:2018-11-23 发布日期:2019-01-23
通讯作者: 徐超,博士,副研究员,主要从事特种动物饲养研究,E-mail:xuchao@caas.cn
作者简介:韩志强(1993-),男,吉林长春人,硕士,主要从事特种经济动物饲养研究,E-mail:hanzhiqiang5113@163.com;宋兴超(1982-),男,河北保定人,博士,助理研究员,主要从事特种经济动物遗传育种研究,E-mail:songxingchao@caas.cn
基金资助:
吉林省产业创新专项（2016C097）；吉林省优秀青年基金（20180520032JH）；中国科协青年人才托举工程（2017QNRC001）；中国农业科学院科技创新工程（ASTIP-ISAPS01）

The Function of miRNA in Mammalian Pregnancy

HAN Zhi-qiang^1,2, SONG Xing-chao¹, WANG Hai-jun³, JIA Yun⁴, ZHAO Jia-ping¹, ZHAO Quan-min², XING Xiu-mei¹, XU Chao^1*

1. Ministry of Agriculture, State Key Laboratory of Special Economic Animal Molecular Biology, Key Laboratory of Special Economic Animal Genetic, Breeding and Reproduction of Ministry of Agriculture, Institute of Special Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, Changchun 130112, China;
2. Jilin Agricultural University, Changchun 130118, China;
3. Jilin Wild Animal Conservation and Breeding Center, Changchun 130119, China;
4. Liaoning Entry-Exit Inspection and Quarantine Bureau, Dalian 116001, China

Received:2018-03-05 Online:2018-11-23 Published:2019-01-23

摘要/Abstract

摘要：

近年来，哺乳动物miRNA与妊娠的关系已成为研究动物妊娠方面的热点。动物体内许多miRNA能够在胎盘中优先表达，并且与妊娠和出生相关。本文结合哺乳动物miRNA对胚胎发育、怀孕、妊娠疾病及围产后期母乳产生等相关研究进行讨论和分析，总结了迄今为止哺乳动物血液和胎盘组织中miRNA对妊娠的作用，以期为研究miRNA与哺乳动物妊娠的关系提供参考。

关键词: miRNA, 妊娠, 胚胎, 生物标记物

Abstract:

In recent years, the relationship between miRNA and pregnancy in mammals has become a hot topic. The majority of miRNA can be preferentially expressed in the animal placenta, and they are related to pregnancy and birth of mammals. The effects of miRNA on embryo development, pregnancy, pregnancy diseases and breast milk production in the late perinatal period in mammals were analysed and discussed in this paper. The effects of miRNA in mammalian blood and placenta on pregnancy were summarized, wihch will provide some references for comprehending the relationship between miRNA and mammalian pregnancy.

Key words: miRNA, pregnancy, embryo, biomarker

中图分类号:

S813.1

韩志强, 宋兴超, 王海军, 贾赟, 赵家平, 赵全民, 邢秀梅, 徐超. 哺乳动物妊娠中miRNA的作用[J]. 畜牧兽医学报, 2018, 49(11): 2310-2316.

HAN Zhi-qiang, SONG Xing-chao, WANG Hai-jun, JIA Yun, ZHAO Jia-ping, ZHAO Quan-min, XING Xiu-mei, XU Chao. The Function of miRNA in Mammalian Pregnancy[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2018, 49(11): 2310-2316.

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哺乳动物妊娠中miRNA的作用

The Function of miRNA in Mammalian Pregnancy

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