黑素小体在黑色素生成过程中的关键作用

doi:10.11843/j.issn.0366-6964.2016.08.002

畜牧兽医学报 ›› 2016, Vol. 47 ›› Issue (8): 1531-1538.doi: 10.11843/j.issn.0366-6964.2016.08.002

黑素小体在黑色素生成过程中的关键作用

杜站宇^1，2，赵家平²，宋兴超²，李雪娇³，吴琼²，杨颖²，邢秀梅²，徐超^1，2* ，张林波^1*

（1.吉林农业大学，长春 130118；2.中国农业科学院特产研究所，农业部特种经济动物遗传育种与繁殖重点实验室，吉林省特种经济动物分子生物学省部共建国家重点实验室，长春 130112；3.长春长生生物科技有限责任公司，长春130103）

收稿日期:2016-03-22 出版日期:2016-08-23 发布日期:2016-09-08
通讯作者: 徐超,助理研究员，主要从事特种动物种质资源与遗传育种研究，E-mail：xuchao@caas.cn;张林波,教授，主要从事生物化学与分子免疫学研究，E-mail：cczlb@163.com
作者简介:杜站宇（1990-），吉林人，男，硕士生，主要从事生物化学与分子生物学研究，E-mail: 735712137@qq.com
基金资助:
吉林省科技发展计划（20130206029NY）；中国农业科学院科技创新工程（ASTIP-ISAPS01）；特种动物种质资源共享平台

The Key Role of Melanosomes in Melanin Production

DU Zhan-yu ^1.2，ZHAO Jia-ping²，SONG Xing-chao²，LI Xue-jiao³，WU Qiong²，YANG Ying²，XING Xiu-mei²，XU Chao ^2* ，ZHANG Lin-bo^1*

（1.Jilin Agricultural University，Changchun 130118，China；2.Key Laboratory of Special Economic Animal Genetic Breeding and Reproduction，Ministry of Agriculture，State Key Laboratory of Special Economic Animal Molecular Biology，Institute of Special Animal and Plant Science，Chinese Academy of Agricultural Sciences，Changchun 130112，China；3.Changchun Changsheng Biotechnology Co.Ltd.，Changchun 130103，China）

Received:2016-03-22 Online:2016-08-23 Published:2016-09-08

摘要/Abstract

摘要：

黑素小体是真核生物细胞中用于合成和沉积黑色素唯一的细胞器，其功能紊乱将导致人类或哺乳动物的色素相关疾病。黑素小体的发生（黑素小体的形成、成熟；前黑素小体纤维的形成；黑素小体相关蛋白的转运）、黑素小体内环境的稳定和黑素小体的转运都是黑色素合成和沉积必不可少的前提条件。本文将对黑素小体在黑色素生成过程中的关键作用进行阐述，以期为哺乳动物黑色素减退机制进一步探索和理解，以及人类白化相关疾病的进一步揭示提供理论参考。

关键词: 黑素小体, 黑素小体的发生, 黑素小体内环境, 黑色素减退

Abstract:

The melanosomes are the only organelles which synthesize and deposit melanin in eukaryotic cells.The dysfunction of melanosomes will lead to pigment related diseases in human or mammalian.Biogenesis of melanosomes (melanosome formation and maturation，the premelanosome fiber formation and melanosome protein transportation)，the balance of melanosome internal environment and melanosome transportation are essential prerequisite for melanin synthesis and deposition.To review the parameters of melanosomes will be helpful to further understand the result of hypopigmentation in mammalian，revealing the human albinism related diseases and providing a theoretical reference.

Key words: melanosome, melanin biosynthesis, internal environment of melanosome, hypopigmentation

中图分类号:

S811

杜站宇，赵家平，宋兴超，李雪娇，吴琼，杨颖，邢秀梅，徐超，张林波. 黑素小体在黑色素生成过程中的关键作用[J]. 畜牧兽医学报, 2016, 47(8): 1531-1538.

DU Zhan-yu，ZHAO Jia-ping，SONG Xing-chao，LI Xue-jiao，WU Qiong，YANG Ying，XING Xiu-mei，XU Chao，ZHANG Lin-bo. The Key Role of Melanosomes in Melanin Production[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2016, 47(8): 1531-1538.

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黑素小体在黑色素生成过程中的关键作用

The Key Role of Melanosomes in Melanin Production

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