支持细胞调控精原干细胞增殖、分化和凋亡的研究进展

doi:10.11843/j.issn.0366-6964.2016.02.003

畜牧兽医学报 ›› 2016, Vol. 47 ›› Issue (2): 225-231.doi: 10.11843/j.issn.0366-6964.2016.02.003

支持细胞调控精原干细胞增殖、分化和凋亡的研究进展

梁洺源^1，2，朱化彬²，陈晓丽²，郝海生²，赵学明²，秦彤²，王栋^2*

（1.吉林农业大学动物科学技术学院，长春 130118； 2.中国农业科学院北京畜牧兽医研究所，农业部畜禽遗传资源与利用重点开放实验室，北京100193）

收稿日期:2015-07-08 出版日期:2016-02-23 发布日期:2016-02-23
通讯作者: 王栋，研究员，博导，主要从事动物遗传育种与繁殖研究，E-mail：dwangcn2002@vip.sina.com
作者简介:梁洺源(1989-)，女，河北燕郊人，硕士，主要从事动物遗传育种与繁殖研究，E-mail：mingyuanliang@163.com
基金资助:
奶牛产业技术体系北京创新团队项目；中国农业科学院家畜胚胎工程与繁殖创新团队项目（cxgc-ias-06）；国家十二五科技支撑计划课题资助项目（2011BAD19B02）

The Study Progress of the Proliferation，Differentiation and Apoptosis of Spermatogonial Stem Cells under the Regulation of Sertoli Cells

LIANG Ming-yuan^1，2，ZHU Hua-bin²，CHEN Xiao-li²，HAO Hai-sheng²，ZHAO Xue-ming²，QIN Tong²，WANG Dong^2*

(1.College of Animal Science and Technology，Jilin Agricultural University，Changchun 130118，China；2.The Key Laboratory for Farm Animal Genetic and Utilization of Ministry of Agriculture of China，Institute of Animal Science，Chinese Academy of Agricultural Sciences，Beijing 100193，China)

Received:2015-07-08 Online:2016-02-23 Published:2016-02-23

摘要/Abstract

摘要：

精原干细胞（Spermatogonial stem cells，SSCs）在支持细胞（Sertoli cells，SCs）调控下有序增殖、分化、凋亡，维持雄性动物正常的精子发生。本文主要对SCs与SSCs的生理结构关系及SCs通过GDNF、FGF2、RA、BMP4、SCF、FasL和SR-BI对SSCs增殖、分化与凋亡的调控进行综述。为精子发生机理的深入研究提供重要参考，将对提高雄性动物繁殖效率具有重要意义，还为探索男性不育疾病的临床治疗方法提供有价值的参考。

关键词: 精原干细胞, 支持细胞, 增殖, 分化, 凋亡

Abstract:

The proliferation，differentiation and apoptosis of spermatogonial stem cells (SSCs) are regulated orderly by sertoli cells (SCs) and maintain the spermatogenesis of male animals.This review focuses on the relationship of physical structure between SCs and SSCs，and the regulation for the proliferation，differentiation and apoptosis of SSCs by GDNF，FGF2，RA，BMP4，SCF，FasL and SR-BI which are SCs-derived factors.This information provides an important reference for the further studies of spermatogenesis and will have great significance to improve reproductive efficiency of male animals，and also provides a valuable reference to explore the clinical treatment of male infertility disease.

Key words: spermatogonial stem cells, sertoli cells, proliferation, differentiation, apoptosis

中图分类号:

S814

梁洺源，朱化彬，陈晓丽，郝海生，赵学明，秦彤，王栋. 支持细胞调控精原干细胞增殖、分化和凋亡的研究进展[J]. 畜牧兽医学报, 2016, 47(2): 225-231.

LIANG Ming-yuan，ZHU Hua-bin，CHEN Xiao-li，HAO Hai-sheng，ZHAO Xue-ming，QIN Tong，WANG Dong. The Study Progress of the Proliferation，Differentiation and Apoptosis of Spermatogonial Stem Cells under the Regulation of Sertoli Cells[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2016, 47(2): 225-231.

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支持细胞调控精原干细胞增殖、分化和凋亡的研究进展

The Study Progress of the Proliferation，Differentiation and Apoptosis of Spermatogonial Stem Cells under the Regulation of Sertoli Cells

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