甲型流感病毒NS1、NS2和NS3蛋白的研究进展

doi:10.11843/j.issn.0366-6964.2014.12.001

摘要/Abstract

摘要：

甲型流感病毒基因组含有8个基因节段，其中血凝素（HA）、神经氨酸酶（NA）、NP核蛋白（NP）及碱性聚合酶2（PB2）基因只能分别编码1个病毒蛋白质。而 M基质蛋白（M）、碱性聚合酶1（PB1）、酸性聚合酶（PA）及NS非结构蛋白（NS）的基因均可编码2种以上的蛋白质，使得甲型流感病毒基因组编码的蛋白质种类多达17种。研究发现M基因编码M1、M2和M42 3种蛋白质；PB1基因编码PB1、PB1-F2和PB1-N40 3种蛋白质；PA基因编码PA、PA-X、PA-N155及PA-N182 4种蛋白质；NS基因则编码NS1、NS2 和NS3 3种蛋白质。NS3蛋白于2012年首次报道，它是由NS3 mRNA编码的1种新的流感病毒蛋白质。作者将对流感病毒NS基因编码的NS1、NS2和NS3 3种蛋白质的研究进展作简要的介绍。

关键词: , 甲型流感病毒, mRNA选择性剪接, NS1蛋白, 细胞核外转运蛋白, NS3蛋白

Abstract:

The genome of influenza A virus consists of eight gene segments.Among them，genes of haemagglutinin (HA)，neuraminidase (NA)，nucleoprotein (NP) and PB2 (basic polymerase 2) can only encode single viral protein，respectively.Genes encoding M (matrix protein)，PB1 (basic polymerase 1)，PA (acidic polymerase) and NS (nonstructural protein) proteins can encode more than two viral proteins.This has made the total number of proteins encoded by influenza A virus become 17.It has been found that M gene encodes M1，M2 and M42 proteins，and that PB1 gene encodes PB1，PB1-F2 and PB1-N40 proteins，respectively.PA gene encodes PA，PA-X，PA-N155 and PA-N182，respectively，whereas NS gene encodes NS1，NS2 and NS3 proteins，respectively.It was first reported by M.Selman et al.that a novel viral protein NS3 of influenza A virus was encoded by NS3 mRNA.This review will briefly introduce progress in research on NS1，NS2 and NS3 proteins encoded by influenza A virus NS gene.

Key words: influenza A virus, mRNA alternative splicing, NS1 protein, nuclear export protein, NS3 protein

中图分类号:

S852.659.5

谭伟，谢芝勋. 甲型流感病毒NS1、NS2和NS3蛋白的研究进展[J]. 畜牧兽医学报, 2014, 45(12): 1911-1916.

TAN Wei，XIE Zhi-xun. An Overview of Research Progress on NS1，NS2 and NS3 Proteins of Influenza A Viruses[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2014, 45(12): 1911-1916.

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