施马伦贝格病研究进展

doi:10.11843/j.issn.0366-6964.2014.07.001

摘要/Abstract

摘要：

施马伦贝格病是自2011年夏季以来在欧洲新发的一种虫媒性病毒病，其病原为施马伦贝格病毒，主要感染绵羊、牛和山羊等反刍动物，可导致成年家畜生产性能下降，怀孕母畜发生流产、产死胎或畸形胎儿。截至目前，中国尚未出现相关疫情。笔者将从病原学、流行病学、临床症状、发病机制与病理变化、检疫与诊断、预警与防控等方面对取得的最新研究进展进行概述，以期增强人们对该病的认识，并为中国有关部门采取恰当的防控措施提供科学依据。

关键词: 施马伦贝格病, 施马伦贝格病毒, 虫媒性病毒病, 检疫, 防控

Abstract:

Schmallenberg disease is a newly emerged arboviral disease in Europe since the summer of 2011.The causative agent of the disease is Schmallenberg virus (SBV) which primarily infects ruminants such as sheep，cattle and goats.The virus can cause declines in the production performance of adult animals，and lead to abortions in pregnant animals and severe fetal malformations or stillbirths.To date，there has been no report of SBV infection in China.In order to enhance the awareness of the disease and to provide the related departments of our country with scientific bases for the prevention and control of this disease，the latest research progress in the aspects of etiology，epidemiology，clinical symptoms，pathogenesis and pathologic changes，quarantine and diagnosis，early warning，prevention and control of the disease will be summarized in this review.

Key words: Schmallenberg disease;Schmallenberg virus (SBV), arboviral disease, quarantine, prevention and control

中图分类号:

张永宁，吴绍强，林祥梅. 施马伦贝格病研究进展[J]. 畜牧兽医学报, 2014, 45(7): 1029-1037.

ZHANG Yong-ning，WU Shao-qiang，LIN Xiang-mei. The Research Progress of Schmallenberg Disease[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2014, 45(7): 1029-1037.

参考文献

［1］HOFFMANN B，SCHEUCH M，HÖPER D，et al.Novel orthobunyavirus in Cattle，Europe，2011［J］.Emerg Infect Dis，2012，18(3)：469-472.
［2］VARELA M，SCHNETTLER E，CAPORALE M，et al.Schmallenberg virus pathogenesis，tropism and interaction with the innate immune system of the host［J］.PLoS Pathog，2013，9(1)：e1003133.
［3］张永宁，吴绍强，刘建，等.欧洲暴发施马伦贝格病疫情及我国应采取的对策［J］.中国兽医杂志，2012，48（4）：92-95.
［4］张永宁，吴绍强，吕继洲，等.施马伦贝格病毒核衣壳蛋白的原核表达、纯化及多克隆抗体的制备［J］.畜牧兽医学报，2013，44（10）：1629-1636.
［5］刘国平，郝善宝，虞以新.中国库蠓属的区系分布［J］.中国媒介生物学及控制杂志，2002，13（3）：196-199.
［6］GOLLER K V，HÖPER D，SCHIRRMEIER H，et al.Schmallenberg virus as possible ancestor of Shamonda virus［J］.Emerg Infect Dis，2012，18(10)：1644-1646.
［7］DOCEUL V，LARA E，SAILLEAU C，et al.Epidemiology，molecular virology and diagnostics of Schmallenberg virus，an emerging orthobunyavirus in Europe［J］.Vet Res，2013，44：31.
［8］FISCHER M，HOFFMANN B，GOLLER K V，et al.A mutation ‘hot spot’ in the Schmallenberg virus M segment［J］. J Gen Virol，2013，94(Pt6)：1161-1167.
［9］COUPEAU D，CLAINE F，WIGGERS L，et al.In vivo and in vitro identification of a hypervariable region in Schmallenberg virus［J］.J Gen Virol，2013，94(Pt6)：1168-1174.
［10］BILK S，SCHULZE C，FISCHER M，et al.Organ distribution of Schmallenberg virus RNA in malformed newborns［J］.Vet Microbiol，2012，159(1-2)：236-238.
［11］BRÉARD E，LARA E，COMTET L，et al.Validation of a commercially available indirect ELISA using a nucleocapside recombinant protein for detection of Schmallenberg virus antibodies［J］.PLoS One，2013，8(1)：e53446.
［12］HOFFMANN B，SCHULZ C，BEER M.First detection of Schmallenberg virus RNA in bovine semen，Germany，2012［J］.Vet Microbiol，2013，167(3-4)：289-295.
［13］DONG H，LI P，BÖTTCHER B，et al.Crystal structure of Schmallenberg orthobunyavirus nucleoprotein-RNA complex reveals a novel RNA sequestration mechanism［J］.RNA，2013，19(8)：1129-1136.
［14］VAN DER HEIJDEN H M，BOUWSTRA R J，MARS M H，et al.Development and validation of an indirect enzyme-linked immunosorbent assay for the detection of antibodies against Schmallenberg virus in blood samples from ruminants［J］.Res Vet Sci，2013，95(2)：731-735.
［15］OIE.OIE Technical Factsheet Schmallenberg Virus，November 2013 ［DB］.http://www.oie.int/fileadmin/Home/eng/Our_scientific_expertise/docs/pdf/A_Schmallenberg_virus.pdf.OIE，Paris，France(2013).
［16］DE REGGE N，VAN DEN BERG T，GEORGES L，et al.Diagnosis of Schmallenberg virus infection in malformed lambs and calves and first indications for virus clearance in the fetus［J］.Vet Microbiol，2013，162(2-4)：595-600.
［17］VAN DER POEL W H，PARLEVLIET J M，VERSTRATEN E R，et al.Schmallenberg virus detection in bovine semen after experimental infection of bulls［J］.Epidemiol Infect，2013，9：1-6.
［18］SCHULZ C，WERNIKE K，BEER M，et al.Infectious schmallenberg virus from bovine semen，Germany［J］.Emerg Infect Dis，2014，20(2)：338-340.
［19］DE REGGE N，DEBLAUWE I，DE DEKEN R，et al.Detection of Schmallenberg virus in different Culicoides spp.by real-time RT-PCR［J］. Transbound Emerg Dis，2012，59(6)：471-475.
［20］ELBERS A R，MEISWINKEL R，VAN WEEZEP E，et al.Schmallenberg virus in Culicoides spp.biting midges，the Netherlands，2011［J］.Emerg Infect Dis，2013，19(1)：106-109.
［21］LARSKA M，LECHOWSKI L，GROCHOWSKA M，et al.Detection of the Schmallenberg virus in nulliparous Culicoides obsoletus/scoticus complex and C.punctatus--the possibility of transovarial virus transmission in the midge population and of a new vector［J］.Vet Microbiol，2013，166(3-4)：467-473.
［22］RASMUSSEN L D，KRISTENSEN B，KIRKEBY C，et al.Culicoids as vectors of Schmallenberg virus［J］.Emerg Infect Dis，2012，18(7)：1204-1206.
［23］VERONESI E，HENSTOCK M，GUBBINS S，et al.Implicating Culicoides biting midges as vectors of Schmallenberg virus using semi-quantitative RT-PCR［J］. PLoS One，2013，8(3)：e57747.
［24］SCHOLTE E J，MARS M H，BRAKS M，et al.No evidence for the persistence of Schmallenberg virus in overwintering mosquitoes［J］.Med Vet Entomol，2014，28(1)：110-115.
［25］WERNIKE K，ESCHBAUMER M，SCHIRRMEIER H，et al.Oral exposure，reinfection and cellular immunity to Schmallenberg virus in cattle［J］.Vet Microbiol，2013，165(1-2)：155-159.
［26］CHIARI M，SOZZI E，ZANONI M，et al.Serosurvey for Schmallenberg virus in Alpine wild ungulates［J］.Transbound Emerg Dis，2014，61(1)：1-3.
［27］WENSMAN J J，BLOMQVIST G，HJORT M，et al.Presence of antibodies to Schmallenberg virus in a dog in Sweden［J］. J Clin Microbiol，2013，51(8)：2802-2803.
［28］SAILLEAU C，BOOGAERTS C，MEYRUEIX A，et al.Schmallenberg virus infection in dogs，France，2012［J］.Emerg Infect Dis，2013，19(11)：1896-1898.
［29］WERNIKE K，SILAGHI C，NIEDER M，et al.Dynamics of Schmallenberg virus infection within a cattle herd in Germany，2011 ［J］.Epidemiol Infect，2014，142（7）：1501-1504.
［30］WERNIKE K，KOHN M，CONRATHS F J，et al.Transmission of Schmallenberg virus during Winter，Germany［J］.Emerg Infect Dis，2013，19(10)：1701-1703.
［31］SEDDA L，ROGERS D J.The influence of the wind in the Schmallenberg virus outbreak in Europe［J/OL］.Sci Rep，2013，3：3361.http://www.nature.com/srep/2013/131128/srep03361/pdf/srep03361.pdf
［32］EFSA.“Schmallenberg” virus：analysis of the epidemiological data.(May 2013) Supporting Publications 2013：EN-429 ［DB/OL］.2013.http://www.efsa.europa.eu/en/search/doc/429e.pdf.
［33］WERNIKE K，HOFFMANN B，BRÉARD E，et al.Schmallenberg virus experimental infection of sheep［J］.Vet Microbiol，2013，166(3-4)：461-466.
［34］HERDER V，WOHLSEIN P，PETERS M，et al.Salient lesions in domestic ruminants infected with the emerging so-called Schmallenberg virus in Germany［J］.Vet Pathol，2012，49(4)：588-591.
［35］GARIGLIANY M M，BAYROU C，KLEIJNEN D，et al.Schmallenberg virus：a new Shamonda/Sathuperi-like virus on the rise in Europe［J］.Antiviral Res，2012，95(2)：82-87.
［36］CONRATHS F J，PETERS M，BEER M.Schmallenberg virus，a novel orthobunyavirus infection in ruminants in Europe：potential global impact and preventive measures［J］.N Z Vet J，2013，61(2)：63-67.
［37］EFSA.“Schmallenberg” virus：likely epidemiological scenarios and data needs.Supporting Publications 2012：EN-241 ［DB/OL］.2012.http://www.efsa.europa.eu/en/supporting/doc/241e.pdf.
［38］WERNIKE K，HOFFMANN B，BEER M.Schmallenberg virus［J］. Dev Biol (Basel)，2013，135：175-182.
［39］PEPERKAMP K，DIJKMAN R，VAN MAANEN C，et al.Polioencephalo-myelitis in a calf due to infection with Schmallenberg virus［J］.Vet Rec，2012，170(22)：570.
［40］HAHN K，HABIERSKI A，HERDER V，et al.Schmallenberg virus in central nervous system of ruminants［J］.Emerg Infect Dis，2013，19(1)：154-155.
［41］HERDER V，HANSMANN F，WOHLSEIN P，et al.Immunophenotyping of inflammatory cells associated with Schmallenberg virus infection of the central nervous system of ruminants［J］.PLoS One，2013，8(5)：e62939.
［42］FISCHER M，SCHIRRMEIER H，WERNIKE K，et al.Development of a pan-Simbu real-time reverse transcriptase PCR for the detection of Simbu serogroup viruses and comparison with SBV diagnostic PCR systems［J］.Virol J，2013，10：327.
［43］ZHANG Y，WU S，WANG J，et al.Expression and purification of the nucleocapsid protein of Schmallenberg virus，and preparation and characterization of a monoclonal antibody against this protein［J］.Protein Expr Purif，2013，92(1)：1-8.
［44］张永宁，吴绍强，WERNIKE K，等.施马伦贝格病毒核衣壳蛋白单克隆抗体的制备及其特性分析［J］.细胞与分子免疫学杂志，2014，30（3）：289-293.
［45］DUCOMBLE T，WILKING H，STARK K，et al.Lack of evidence for Schmallenberg virus infection in highly exposed persons，Germany，2012［J］.Emerg Infect Dis，2012，18(8)：1333-1335.
［46］REUSKEN C，VAN DEN WIJNGAARD C，VAN BEEK P，et al.Lack of evidence for zoonotic transmission of Schmallenberg virus［J］.Emerg Infect Dis，2012，18(11)：1746-1754.
［47］WERNIKE K，NIKOLIN V M，HECHINGER S，et al.Inactivated Schmallenberg virus prototype vaccines［J］.Vaccine，2013，31(35)：3558-3563.

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