羊毛及动物毛发弯曲形成的生物学机理研究进展

doi:10.11843/j.issn.0366-6964.2014.05.001

摘要/Abstract

摘要：

弯曲是羊毛纤维的一个特征，对加工过程和最终的毛纺织品特性有显著影响。羊毛弯曲与毛囊中细胞的不对称分裂、毛纤维中正副皮质的双边排列、不同角蛋白的不对称组成及角质化过程等相关。尽管羊毛弯曲形成的分子机理鲜有报道，但小鼠锯齿状及波纹状毛发分子调控机理研究表明，IGFBP5/Krox20、Eda/Edar、Wnt、EGFR/TGF-α、Msx2/Foxn1/Ha3等介导的信号通路及毛发角蛋白基因和一些转录因子对纤维弯曲形成有重要影响。皮肤基因表达模式比较分析表明，哺乳动物毛发产生和发育的分子调控机理是相似的。这些信息为研究羊毛弯曲形成的分子机理提供了可能。本文旨在对羊毛及小鼠等动物毛发弯曲形成机理进行综述，为进一步解析羊毛弯曲形成分子机理进而为改善羊毛弯曲性状的研究提供参考。

关键词: 羊毛, 毛发, 弯曲, 机理

Abstract:

Crimp is an important characteristic of wool fiber，and significantly affects wool value，processing and final fabric attributes.Wool crimp is associated with the asymmetric cell division in follicles，well-defined bilateral structure of orthocortex and paracortex，differences in the expression of keratins and keratin-associated proteins and keratinization in fiber.Although rare study was reported on the molecular mechanism of wool crimp formation，the studies in mice showed that these signal pathways of IGFBP5/Krox20，Eda/Edar，Wnt，EGFR/TGF-α，Msx2/Foxn1/Ha3 and several keratin genes and transcription factors have significant influence on the formation of zigzag and waved hair.Comparative analyses of gene expression patterns in skin suggest that the molecular regulation of the basic mechanisms of follicle initiation，development and fiber production are similar in most mammals，which offer available information for studying molecular regulation mechanism of wool crimps.The advances on formation mechanism of wool and hair crimps are reviewed in this article in order to further promote the study on the molecular mechanism of wool crimps.

Key words: wool, hair, crimp, mechanism

中图分类号:

S826
S813.24

路立里，狄江，王琼，于丽娟，拉扎特·艾尼瓦尔. 羊毛及动物毛发弯曲形成的生物学机理研究进展[J]. 畜牧兽医学报, 2014, 45(5): 679-685.

LU Li-li， DI Jiang， WANG Qiong， YU Li-juan， Lazate·AINIWAER. Research Advances on the Biological Formation Mechanism of Wool and Hair Crimps[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2014, 45(5): 679-685.

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