Abstract: The aim of this study was to analyze the immunological response to Echinococcus granulosus in Chinese Merino (Xinjiang Army Wasteland Reclamation) sheep with different MHC-DRB1/DQB1 haplotypes. 16 two-year-old female healthy Chinese Merino sheep with different haplotypes were artifically infected with Echinococcus granulosus under the same raising condition, which were divided into two groups: the test group (8 resistant haplotyoe sheep ) and the control group (8 nonresistant haplotype individuals ). The percentage of CD4⁺ T, CD8⁺ T and B lymphocyte subpopulations in peripheral blood were analyzed by flow cytometry on 7 day before infection（－7），and on 0(the day of infection)，7，21，30 and 60 day after infection, respectively. During the same period, the content of IgG, IgM, IgE, IFN-γ in the serum were quantitatively assayed by ELISA and the quantity of granulocyte were counted on Wright’s stained blood smears The results showed that: 1) the incidence of Cystic Echinococcosis in the test group was significantly lower than that in the control group (P=0.019).2) The percentage of CD4⁺ T cells had no significant difference between the two groups (P＞0.05). The percentage of CD8⁺ T cells in the test group was significantly higher than that in the control group (P＜0.05) at day 7. 3) Serum levels of IgG in the two groups were significantly higher at day 7 when compared to day (－7) (P＜0.05).Compared with the test group, significantly higher IgM and IFN-γ occurred in the control group at day 30 (P＜0.05). 4) Leukocytes and lymphocytes in the test group were significantly more than that in the control group (P＜0.05) at day 7 and 21.Neutrophils and albumin in the test group were obviously lower than that in the control group (P＜0.01) at day 21.The significantly higher resistance to Echinococcus granulosus occurred in the resistant haplotype sheep, when compared with the nonresistant haplotype individuals. In addition, the levels of CD8⁺ T cells, IgM, IFN-γ, leukocytes and lymphocytes in the resistant haplotype sheep were significantly higher than those in nonresistant haplotype individuals during the different periods after infection.