替米考星明胶微球在兔体内的靶向性研究

畜牧兽医学报 ›› 2009, Vol. 40 ›› Issue (7): 1097-1100.doi:

替米考星明胶微球在兔体内的靶向性研究

远立国^1，2，李成明³，鲍杰⁴，朱理想²，张秀英¹*

1.东北农业大学动物医学院，哈尔滨 150030； 2.华南农业大学兽医学院，广州 510642； 3.佳木斯市郊区畜牧局，佳木斯 154004； 4.北京市动物卫生监督所，北京 100044

收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2009-07-24 发布日期:2009-07-24
通讯作者: 张秀英

Study on Targeting of Tilmicosin Gelatine Microsphere in Rabbits

YUAN Liguo ^1,2, LI Chengming ³, BAO Jie ⁴, ZHU Lixiang ²， ZHANG Xiuying ¹*

1.College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China；2.College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China； 3.Jiamusi Suburban Husbandry Bureau, Jiamusi 54004, China； 4.Beijing Animal Sanitary Control Station, Beijing 100044, China

Received:1900-01-01 Revised:1900-01-01 Online:2009-07-24 Published:2009-07-24
Contact: ZHANG Xiuying

摘要/Abstract

摘要： 作者旨在研究替米考星明胶微球在兔体内的靶向性。采用高效液相色谱法测定肌内注射给药不同时间兔体各脏器组织的药物浓度，利用3p97药动学软件无房室模型计算药时曲线下面积，结果显示替米考星明胶微球肺脏的靶向效率较心脏、肌肉、肝脏和肾脏提高了518±013、311±006、394±006和374±002倍；肺脏、心脏、肌肉、肝脏和肾脏的相对摄取率分别为823±004、159±003、265±004、209±002和220±001；肺脏、心脏、肌肉、肝脏和肾脏的峰浓度比分别为222±004、042±002、046±001、061±002和071±002。表明替米考星明胶微球具有良好的肺靶向性，同时可以减轻替米考星的心脏毒性。

Abstract: The purpose of this study was to evaluate tilmicosin gelatine microsphere targeting. The timed tilmicosin concentrations of organs from tilmicosin gelatine microsphere and injection administered rabbits were detected with high performance liquid chromatography, and the area under curve was calculated with no compartment model by 3p97, a software of pharmacokinetics. Targeting parameters of tilmicosin gelatine microsphere were analysed. Compared with tilmicosin injection, lung targeting efficiency to heart′s, muscle′s, liver′s and kidney′s was elevated by 518±013, 311±006, 394±006, 374±002 times, respectively. Relative intake rate of lung, heart, muscle, liver and kidney was 823±004, 159±003, 265±004, 209±002 and 220±001. The ratio of peak concentration of lung, heart, muscle, liver and kidney was 222±004, 042±002, 046±001, 061±002 and 071±002, respectively. It was concluded that tilmicosin gelatine microsphere had better lung targeting and alleviated the tilmicosininduced cardiotoxicity.

远立国;李成明;鲍杰;朱理想;张秀英. 替米考星明胶微球在兔体内的靶向性研究[J]. 畜牧兽医学报, 2009, 40(7): 1097-1100.

YUAN Liguo;LI Chengming;BAO Jie;ZHU Lixiang;ZHANG Xiuying . Study on Targeting of Tilmicosin Gelatine Microsphere in Rabbits[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2009, 40(7): 1097-1100.

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