Abstract: To investigate the effect of Baicalin on abortion model and its impact on cytokines at the maternal-fetal interface,KM mice were divided into 5 groups and all mice except the control were injected with Bromocriptine subcutaneously on days 5 to 7 of pregnancy to establish abortion model. Then the mice in different groups were gavaged with distilled water, 0.1, 0.5, 1 mg Baicalin respectively on days 1 to 7 of gestation while the control group treated with ethanol and distilled water. Samples were collected on day 3, 5, 7, 10 and 12 to calculate abortion rate. The content of interferon (IFN)-γ, interleukin (IL)10, progesterone in serum and uterine supernatant were measured by Enzyme-Linked Immuno-absorbent Assay (ELISA). Results showed that the abortion rate in 1 mg Baicalin group at day 12 of gestation was similar to that of control group, which was significantly different from all the abortion models. The volume of IFN-γ was significantly increased in all groups especially in 1mg Baicalin group throughout the implantation stage (day 5 of gestation). As the gestation progresses, the content of progesterone increased gradually with the significant higher level in 0.5 mg and 1 mg Baicalin groups. These results indicate that Baicalin upregulates the level of progesterone in a dosedependent manner, enhances the secretion of IFN-γ during implantation and down-regulates the IFN-γ production afterwards. These findings suggest that Baicalin can modulate cytokine network in pregnancy and benefit embryo implantation and survival.