Abstract: The purpose of this paper is to investigate the correlation between meteorological factors and Newcastle disease morbidity, and to determine the key factors that affect Newcastle disease. Having built BP neural network forecasting model by Matlab 7.0 software, we tested the performance of the model according to the coefficient of determination (R2) and absolute values of the difference between predictive value and practical morbidity. The results showed that 6 kinds of meteorological factors were determined,and the model′s coefficient of determination was 0.760, and the performance of the model was very good. Finally, we built Newcastle disease forecasting model, and applied BP neural network theory in animal disease forecasting research.