Abstract: A cDNA library was constructed with RNA extracted from the skin tissue of an adult goat, and 392 redundancy ESTs were registered in the GenBank, with the accession numbers of CD051766-CD052157. 319 function known gene were identified based on sequence similarity, among which there are 108 unidentified, 70 gene/protein expression, 43 metabolism, 45 cell structure, 30 cell signaling/cell communication, 15 cell defense /immunity and 8 cell division. Some important candidate genes that have possibly involved in cashmere growth are TGFβ binding protein, the EDRK enriched factor, growth factor receptor, G protein associated receptor, dermal papilla derived protein 2, homeobox gene otx2, kallikrein7, jagged1, thrombospondin1 and p53 inducible protein.