ADP-核糖基化调控精子形成的研究进展

doi:10.11843/j.issn.0366-6964.2022.01.002

畜牧兽医学报 ›› 2022, Vol. 53 ›› Issue (1): 11-19.doi: 10.11843/j.issn.0366-6964.2022.01.002

ADP-核糖基化调控精子形成的研究进展

段晨莹^1,2, 李欣¹, 赵俊金³, 李茹意^1,2, 赵羚均^1,2, 郭冠华^1,4, 杨利国⁵, 滑国华^5*, 王栋^1*

1. 中国农业科学院北京畜牧兽医研究所, 北京 100193;
2. 吉林农业大学动物科学技术学院, 长春 130118;
3. 全国畜牧总站, 北京 100125;
4. 山西农业大学动物科学学院, 太谷 030801;
5. 华中农业大学农业动物遗传育种与繁殖教育部重点实验室, 武汉 430070

收稿日期:2021-03-24 出版日期:2022-01-23 发布日期:2022-01-26
通讯作者: 王栋,主要从事动物遗传育种与繁殖研究,E-mail:dwangcn2002@vip.sina.com;滑国华,主要从事动物遗传育种与繁殖研究,E-mail:huaguohua@mail.hzau.edu.cn
作者简介:段晨莹(1997-),女,山西襄汾人,硕士,主要从事动物遗传育种与繁殖研究,E-mail:duan19970103@163.com
基金资助:
国家自然科学基金（31772595）

Research Progress of ADP-ribosylation in Regulating Spermatogenesis

DUAN Chenying^1,2, LI Xin¹, ZHAO Junjin³, LI Ruyi^1,2, ZHAO Lingjun^1,2, GUO Guanhua^1,4, YANG Liguo⁵, HUA Guohua^5*, WANG Dong^1*

1. Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China;
2. College of Animal Science and Technology, Jilin Agricultural University, Changchun 130118, China;
3. National Animal Husbandry Service, Beijing 100125, China;
4. College of Animal Science, Shanxi Agricultural University, Taigu 030801, China;
5. Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction(Huazhong Agricultural University), Ministry of Education, Wuhan 430070, China

Received:2021-03-24 Online:2022-01-23 Published:2022-01-26

摘要/Abstract

摘要： ADP-核糖基化是由ADP-核糖基转移酶（（ADP-ribosyl） transferases，ARTs）催化的一种蛋白质翻译后修饰，分为聚-ADP-核糖基化和单-ADP-核糖基化，在着丝点和纺锤体组装、DNA损伤修复及精子染色质重塑等多个精子发生生物学事件中发挥重要调控作用。部分ARTs基因缺失使精子形成异常，导致精液质量降低，甚至雄性不育。然而，ADP-核糖基化调控精子形成的详细机制尚不清楚，对单-ADP核糖基化的研究则更少。为此，本文综述了ADP-核糖基化在精子形成中的研究进展，以期为深入揭示精子形成调控机制提供新思路，推动雄性繁殖障碍防控和男性不育治疗取得新突破。

关键词: ADP-核糖基化, 精子形成, 聚-ADP-核糖基聚合酶, ecto-ADP-核糖基转移酶

Abstract: ADP-ribosylation is a kind of post-translational modification of proteins catalyzed by ADP-ribosyl transferases (ARTs). It is divided into poly-ADP-ribosylation and mono-ADP-ribosylation, which plays an important role in regulating many biological events during spermatogenesis, such as assembly of centromere and spindle, DNA damage repair and chromatin condensation. Part of the ARTs gene deletion leads to abnormal spermatogenesis, resulting in reduced semen quality and even male infertility. However, the detailed mechanism of spermatogenesis regulated by ADP-ribosylation is still unclear, and the understand on the role of mono-ADP-ribosylation within it is even less. Therefore, this paper reviews the research progress of ADP-ribosylation in spermatogenesis, hoping to provide new ideas for further revealing the regulatory mechanism of spermatogenesis, and promoting breakthrough in the prevention and control of male reproductive disorders and the treatment of male infertility.

Key words: ADP-ribosylation, spermatogenesis, poly-ADP-ribose polymerases, ecto-ADP-ribosyl transferase

中图分类号:

段晨莹, 李欣, 赵俊金, 李茹意, 赵羚均, 郭冠华, 杨利国, 滑国华, 王栋. ADP-核糖基化调控精子形成的研究进展[J]. 畜牧兽医学报, 2022, 53(1): 11-19.

DUAN Chenying, LI Xin, ZHAO Junjin, LI Ruyi, ZHAO Lingjun, GUO Guanhua, YANG Liguo, HUA Guohua, WANG Dong. Research Progress of ADP-ribosylation in Regulating Spermatogenesis[J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(1): 11-19.

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ADP-核糖基化调控精子形成的研究进展

Research Progress of ADP-ribosylation in Regulating Spermatogenesis

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