群体感应分子——法尼醇与白色念珠菌的相互作用

doi:10.11843/j.issn.0366-6964.2019.01.004

摘要/Abstract

摘要：

群体感应最早在细菌中发现，近年来也陆续发现存在于真菌中。群体感应中的关键信号分子被称为群体感应分子，是由微生物自身所分泌、感知、响应并作用于其自身，在引起反应的浓度时对其自身没有毒性的一类物质。法尼醇是白色念珠菌的群体感应分子，影响白色念珠菌的耐药性、菌丝形成、黏附力和凋亡；影响白色念珠菌宿主机体的免疫及宿主细胞的凋亡。此外，白色念珠菌对法尼醇具有高于其他真菌的耐受性，但这种机制尚不明确。目前对群体感应分子法尼醇的作用机制缺乏了解，本文就群体感应分子法尼醇与白色念珠菌之间的相互作用展开综述。

Abstract:

Quorum sensing (QS) was first discovered in bacteria. It has also been found in fungi in recent years. The key signal molecule of QS are called Quorum sensing molecules (QSM), which excreting, sensing, responsing and acting on itself, and having no toxic action on itself when at the concentration that just cause the reaction. Farnesol is the QSM of Candida albicans, which influence multitudes factors of C. albicans including drug resistance, hypha formation, adhesive power and apoptosis; and influence the C. albicans host's immunity and host cell apoptosis. Furthermore, C. albicans has higher tolerance to farnesol than other fungi, but the mechanism is unclear. At present, because of the little understanding on the mechanism of the QSM farnesol, the interaction between the QSM farnesol and C. albicans is reviewed in this paper.

中图分类号:

S852.66

杨瑷宁, 马晓平, 古玉, 俞演, 胡静, 姜尧章, 彭广能, 钟志军, 左之才. 群体感应分子——法尼醇与白色念珠菌的相互作用[J]. 畜牧兽医学报, 2019, 50(1): 28-36.

YANG Aining, MA Xiaoping, GU Yu, YU Yan, HU Jing, JIANG Yaozhang, PENG Guangneng, ZHONG Zhijun, ZUO Zhicai. The Interaction between Farnesol (Quorum Sensing Molecule) and Candida albicans[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2019, 50(1): 28-36.

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