CD4基因的DNA甲基化修饰在家畜抗病育种中的应用

doi:10.11843/j.issn.0366-6964.2017.10.002

Abstract

Abstract:

CD4 molecular is mainly expressed on mature CD4⁺T cells surface. It can direct T cells normal differentiation and maturation, recognize antigen, mediate immune response and involve in immune regulation. DNA methylation modification is critical to regulating differentiation of T cell subsets. Especially, the DNA methylation of CD4 gene can significantly affect the amount and function of CD4⁺T cells, influence the ability of immune response and disease resistance of livestock, then against or adapt environmental changes. Up to date, studies have reported that DNA methylation of porcine and bovine CD4 gene can regulate immune responses of the host cells, while that of sheep and horse are rarely reported. To understand the molecular basis of complex diseases and provide novel breeding strategies against livestock diseases via molecular marker assistant selection methods, the progress on regulation mechanism of DNA methylation of livestock CD4 gene, and its effects on immune responses during CD4⁺T cells differentiation, as well its possible application in disease resistance breeding of livestock were reviewed and discussed in this paper.

CLC Number:

Q953
S813.1

WANG Xiao-shuo, ZHAO Hui-min, TANG Tian, LI Kai, QIAN Xu, ZHANG Xue, TU Ya, ZHENG Yun-sheng, WANG Huai-dong, YU Ying. DNA Methylation Modification of CD4 Gene and Its Application in Livestock Diseases-Resistant Breeding[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2017, 48(10): 1796-1806.

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DNA Methylation Modification of CD4 Gene and Its Application in Livestock Diseases-Resistant Breeding

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