维拉帕米对肉鸡肺动脉高压发生过程中肺动脉平滑肌细胞c-Fos表达的影响

doi:10.11843/j.issn.0366-6964.2015.08.020

Abstract

Abstract:

The c-Fos expression of the pulmonary arterial smooth muscle cells in the development of the pulmonary hypertension in broilers induced by low ambient temperature and the effect of verapamil on c-Fos expression were dynamically studied.One hundred and eighty 14-day-old AA broilers were randomised into three groups，control group (21 ℃±1 ℃)，low temperature group (10 ℃±1 ℃) and verapamil group (10 ℃±1 ℃，add 0.01% verapamil in drinking water).Then their pulmonary arterial pressures were measured；and the lungs of broilers were fixed to study the expression of c-Fos.The results showed that the pulmonary arterial pressure in low temperature group significantly higher than those in control group and verapamil group after exposure to low temperature one week (P<0.05)，the expression of c-Fos in 20-50 μm and 50-100 μm pulmonary arteries in low temperature group were significantly higher than those in control group and verapamil group after exposure to low temperature one and two weeks respectively (P<0.05).The results suggested that the expression of c-Fos in pulmonary arteries were significantly increased and verapamil can prevent the high expression of c-Fos and the increase of pulmonary arterial pressure.

CLC Number:

S852.33

WANG Jian-lin，QIAO Jian. The Effect of Verapamil on the c-Fos Expression of Pulmonary Artery Smooth Muscular Cells in the Development of Pulmonary Hypertension in Broilers Induced by Low Ambient Temperature[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2015, 46(8): 1432-1437.

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The Effect of Verapamil on the c-Fos Expression of Pulmonary Artery Smooth Muscular Cells in the Development of Pulmonary Hypertension in Broilers Induced by Low Ambient Temperature

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