成年克隆巴马小型猪心脏差异蛋白的鉴定与生物信息学分析

Abstract

Abstract:

The aim of this study was to explore the influence of somatic cell nuclear transfer (namely clone) operation on cardiac development of cloned Bama Miniature pigs. The proteins from three adult cloned pigs and three normal reproductive pigs were extracted, separated and identified by using comparative proteomics containing two-dimensinal gel electrophoresis (2-DE) and mass spectrometry (MS). And the functions of some important differential proteins was analyzed by bioinformatics analysis. Compared with controls, there are 11 differential proteins including 5 up-regulated and 6 down-regulated proteins in the hearts from adult cloned Bama Miniature pigs. In the present study, endothelial dysfunction of hearts from three adult cloned Bama Miniature pigs was confirmed at proteomics level.

CLC Number:

S828
S813.3

ZHANG Shu-shan, DAI Jian-jun, WU Cai-feng, ZHANG Ting-yu, ZHANG De-fu. Identification and Bioinformatic Analysis of Differentially Expressed Proteinsof Hearts from Adult Cloned Bama Miniature Pigs[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, doi: .

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References

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Identification and Bioinformatic Analysis of Differentially Expressed Proteinsof Hearts from Adult Cloned Bama Miniature Pigs

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