小鼠早期胚胎发育过程中的DNA去甲基化

Abstract

Abstract:

Epigenetic modifications play essential regulatory roles in gene expression and transcription, cell growth &differentiation, and growth of animal. The abnormality of epigenetic modification can lead to a series of disease during development. From fertilization to implantation, epigenome of embryos undergoes extensive reprogramming, which mainly induce demethylation of 5mC and histone modifications. After fertilization, genome undergoes both active and passive demethylation in mammalian pre-implantation embryos. This paper summarizes proteins related to DNA methlation modification and mechanisms of DNA demethylation, and the dynamic changes of DNA methylation in mouse pre-implantation embryos.

CLC Number:

LIU Qing-qing, ZHENG Li-ming, LIU Hong-liang, SU Jian-min, QUAN Fu-sheng, ZHANG Yong. DNA Demethylation in Mouse Pre-implantation Embryos[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, doi: .

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DNA Demethylation in Mouse Pre-implantation Embryos

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