Abstract: The expressive vector of pGEX-Tsol18-sp was constructed using the genetic modified Tsol18 gene of Taenia solium onchospere by the site-directed mutation of 4 bases in its coding sequence and removing of the sequence fragment encoding its N-terminal signal peptide. After induced with IPTG, the expressed proteins of TSOl18 and TSOl18-sp were probed by SDS-PAGE, Western blot and its stability was evaluated by storing at 4 ℃. The effects of immuno-protection of these two recombinant proteins were compared by ELISA and counting of Cysticercus in the muscle tissue of experimental pigs. The results revealed that the modified Tsol18-sp, in which 7 bases were synonymously mutated, could be expressed in the recombinant pGEX-Tsol18-sp vector. The soluble recombinant protein with a molecular weight of 38.7 ku can be probed by the specific serum against Taenia solium oncosphere, and only 20.1% was degradated in storage at 4 ℃ for 2 months. Both of the recombinant proteins can induce high titre of antibodies in the vaccinated pigs, but the recombinant protein TSOL18-sp showed a better protection rate（100%） against the challenge of Cysticercus cellulose than TSOL18 revealed（20%） by the reduced counts of Cysticercus in the muscle tissue of vaccinated pigs. It was suggested that the TSOL18-SP is a effective and stabile antigen, and could be used as a potential antigen for the immunoprophylaxis of Cysticercosis cellulosae.