过量维生素A对育成期雄性水貂生长性能及血清生化指标的影响

doi:10.11843/j.issn.0366-6964.2018.11.014

Abstract

Abstract:

The aim of this study was to investigate the effects of excessive vitamin A(VA) supplementation on growth performance, nutrient digestibility and serum biochemical indexes of growing male minks. Using a single factor randomized trial design, ninety healthy male minks were randomly assigned to 6 treatment groups with 15 animals in each group and fed a diet supplemented with 0(Control), 5 000(Ⅰ),20 000(Ⅱ), 80 000(Ⅲ), 320 000(Ⅳ) and 1 280 000 IU·kg^-1(Ⅴ) VA (based on dry matter), respectively, the pretest period lasted for 7 days and the formal test period lasted for 60 days. On the 30th day of the trail, 8 minks from each group were selected randomly for the digestion and metabolism test for 3 days, the feces and urine samples were collected by total feces collection method, the contents of dry matter (DM), crude protein (CP) and crude fat (EE) were measured, and the nutrient digestibility was calculated. Blood samples were collected at the end of the test and the contents of blood glucose(GLU), triglyceride(TG),cholesterol(CHO), high density lipoprotein cholesterol(HDL), low density lipoprotein cholesterol(LDL), alkaline phosphatase(ALP), aspartate aminotransferase(AST), alanine aminotransferase(ALT) and lactic dehydrogenase(LDH) were measured. The results showed that:1)Final weight and average daily gain in group Ⅱ was significantly higher than that in group Ⅴ(P<0.05). 2) Compared with control group, VA could improve the digestibility of nutrients (P<0.05), group Ⅱ was all the best. 3) VA had no significant effects on GLU and CHO (P>0.05), TG content in group Ⅴ was significantly higher than that in group Ⅱ(P<0.05). HDL content in group Ⅳ and Ⅴ were significantly lower than that in the other groups (P<0.05). LDL content in group Ⅰ was the lowest, which was significantly lower than that in group Ⅳ and Ⅴ(P<0.05). 4)Serum ALP, AST, ALT and LDH levels were significantly affected by dietary VA (P<0.05). ALP content had a significant difference between group Ⅴ and control, group Ⅲ, Ⅳ(P<0.05). Concentration of serum AST was significantly decreased in group Ⅱ, which was significantly lower than that in control, group Ⅳ, Ⅴ(P<0.05). VA induced a significantly lower concentration of ALT in group Ⅱ(P<0.05), group Ⅴ was higher than control, Ⅰ,Ⅱ groups(P<0.05). Concentration of LDH in group Ⅴ was significantly lower than that in group Ⅰ, Ⅱ, Ⅲ (P<0.05), whereas there was no significant differences between the control group and group Ⅳ(P>0.05). Under the experimental conditions, the supplementation of VA with 5 000-80 000 IU·kg^-1 in diet could improve growth potentials. However, excessive vitamin A supplementation could negatively affects growth and lipid metabolism. Further research is needed to determine the effect mechanism of excessive vitamin A supplementation on the growth of minks.

Key words: mink, vitamin A, growth performance, serum biochemical indices

CLC Number:

NAN Wei-xiao, ZHANG Hai-hua, SI Hua-zhe, MU Lin-lin, LOU Yu-jie, LI Guang-yu. The Effects of Excessive Vitamin A Supplementation on Growth Performance and Serum Biochemical Indices in Growing Male Minks[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2018, 49(11): 2425-2434.

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The Effects of Excessive Vitamin A Supplementation on Growth Performance and Serum Biochemical Indices in Growing Male Minks

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