白藜芦醇和血根碱对2~6月龄犊牛生长性能和血清生化指标的影响

doi:10.11843/j.issn.0366-6964.2018.09.015

Abstract

Abstract:

This study was conducted to investigate the effects of resveratrol (RES) and sanguinarine (SAG) on the growth performance and serum biochemical indexes of 2-6 months old calves. Fifty-four female Holstein calves of 5 days old with average body weight of 42 kg were randomly assigned to 3 groups with 18 calves in each group. Calves were fed one of the following diets:a milk replacer (MR) as the basal diet (MR group), a basal diets supplemented with SAG (0.05 mg·(kg BW)^-1, SAG group) or a basal diet supplemented with RES (4 mg·(kg BW)^-1, RES group). Calves were measured for body weight and body size on 56, 90, 120, 150 and 180 days of age. Blood was collected on 60 and 180 days of age for detecting serum biochemical indexes. The results showed that:1) Compared with MR group, RES supplementation significantly increased the body weight of 180 days old calves (P<0.05). The body weight of 180 days old calves in SAG treatment had a trend to increase (P=0.081 2); 2) In body size, SAG supplementation significantly increased the body height of 150 and 180 days old calves (P<0.05), and hip height of 180 days old calves(P<0.05); 3) Compared with MR group, RES and SAG supplementation significantly decreased serum FFA and INS concentrations of 60 days old calves (P<0.05); RES supplementation significantly increased serum GH, EGF and IGF-Ⅰconcentrations of 60 days old calves (P<0.05); SAG and RES supplementation significantly increased IgA concentrations of 60 days old calves (P<0.05); SAG and RES supplementation had no significant effect on IgG (P>0.05); Serum MDA concentration of 60 days old calves in SAG treatment group were higher than that in MR group (P<0.05). RES and SAG supplementation had no significant effect on serum SOD, GSH-PX and T-AOC concentrations of calves (P>0.05). In conclusion, the addition of RES and SAG in diets increased the body weight and body height of 180 days old calves, respectively, and improved the serum antioxidant indexes of calves.

Key words: calf, plant extracts, resveratrol, sanguinarine, calf breeding

CLC Number:

S823.5

ZHANG Wei-bing, ZHANG Rong, BI Yan-liang, TU Yan, DU Han-chang, TIAN Zhong-hong, DIAO Qi-yu. Effect of Resveratrol and Sanguinarine on Growth Performance and Blood Biochemical Indices of 2-6 Months Old Calves[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2018, 49(9): 1940-1951.

References

[1] 张卫兵,张蓉,屠焰,等.白藜芦醇对动物表观遗传学调控的作用机制[J].动物营养学报,2016,28(5):1302-1308.
ZHANG W B,ZHANG R,TU Y,et al.The mechanism of resveratrol in epigenetics regulation in animals[J].Chinese Journal of Animal Nutrition,2016,28(5):1302-1308.(in Chinese)
[2] 张卫兵,张蓉,屠焰,等.血根碱的作用机制及其在动物营养上的应用效果[J].动物营养学报,2017,29(1):27-33.
ZHANG W B,ZHANG R,TU Y,et al.Sanguinarine:mechanism and its application in animal feeding[J].Chinese Journal of Animal Nutrition,2017,29(1):27-33.(in Chinese)
[3] VIEIRA S L,BERRES J,REIS R N,et al.Studies with sanguinarine like alkaloids as feed additive in broiler diets[J].Rev Bras Cienc Avic,2008,10(1):67-71.
[4] SAHIN K,AKDEMIR F,ORHAN C,et al.Effects of dietary resveratrol supplementation on egg production and antioxidant status[J].Poult Sci,2010,89(6):1190-1198.
[5] KANTAS D,PAPATSIROS V G,TASSIS P D,et al.Effect of a natural feed additive (Macleaya cordata),containing sanguinarine,on the performance and health status of weaning pigs[J].Anim Sci J,2015,86(1):92-98.
[6] BAVARSADI M,MAHDAVI A H,ANSARI-MAHYARI S,et al.Effects of different levels of sanguinarine on antioxidant indices,immunological responses,ileal microbial counts and jejunal morphology of laying hens fed diets with different levels of crude protein[J].J Anim Physiol Anim Nutr,2017,101(5):936-948.
[7] MA T,CHEN D D,TU Y,et al.Effect of dietary supplementation with resveratrol on nutrient digestibility,methanogenesis and ruminal microbial flora in sheep[J].J Anim Physiol Anim Nutr,2015,99(4):676-683.
[8] AGUILAR-HERNÁNDEZ J A,URÍAS-ESTRADA J D,LÓPEZ-SOTO M A,et al.Evaluation of isoquinoline alkaloid supplementation levels on ruminal fermentation,characteristics of digestion,and microbial protein synthesis in steers fed a high-energy diet[J].J Anim Sci,2016,94(1):267-274.
[9] ESTRADA-ANGULO A,AGUILAR-HERNÁNDEZ A,OSUNA-PÉREZ M,et al.Influence of quaternary benzophenantridine and protopine alkaloids on growth performance,dietary energy,carcass traits,visceral mass,and rumen health in finishing ewes under conditions of severe temperature-humidity index[J].Asian-Australas J Anim Sci,2016,29(5):652-658.
[10] MICKDAM E,KHIAOSA-ARD R,METZLER-ZEBELI B U,et al.Rumen microbial abundance and fermentation profile during severe subacute ruminal acidosis and its modulation by plant derived alkaloids in vitro[J].Anaerobe,2016,39:4-13.
[11] 饶华,蔡鹏,周锡红,等.博落回提取物对断奶仔猪生长性能的影响[J].中国兽药杂志,2009,43(11):42-45.
RAO H,CAI P,ZHOU X H,et al.Effects of macleaya cordata extracts on growth performance of weaned piglets[J].Chinese Journal of Veterinary Drug,2009,43(11):42-45.(in Chinese)
[12] 张丽英.饲料分析及饲料质量检测技术[M].3版.北京:中国农业大学出版社,2007:49-151.
ZHANG L Y.Feed analysis and quality test technology[M].3rd ed.Beijing:China Agricultural University Press,2007:49-151.(in Chinese)
[13] ZHANG C,WANG L,ZHAO X H,et al.Dietary resveratrol supplementation prevents transport-stress-impaired meat quality of broilers through maintaining muscle energy metabolism and antioxidant status[J].Poult Sci,2017,96(7):2219-2225.
[14] LIU L L,HE J H,XIE H B,et al.Resveratrol induces antioxidant and heat shock protein mRNA expression in response to heat stress in black-boned chickens[J].Poult Sci,2014,93(1):54-62.
[15] ZHANG C,LUO J Q,YU B,et al.Effects of resveratrol on lipid metabolism in muscle and adipose tissues:a reevaluation in a pig model[J].J Funct Foods,2015,14:590-595.
[16] SERRERO G,LU R Q.Effect of resveratrol on the expression of autocrine growth modulators in human breast cancer cells[J].Antioxid Redox Signal,2001,3(6):969-979.
[17] 杨春涛.热带假丝酵母与桑叶黄酮对犊牛生长和胃肠道发育的影响[D].北京:中国农业科学院,2016.
YANG C T.Effects of Candida tropicalis and mulberry leaf flavonoids on growth and gastrointestinal development in calves[D].Beijing:Chinese Academy of Agricultural Sciences,2016.(in Chinese)
[18] ABDELNABY E A,MOHAMED M F,GAMMAZ H A.Pharmacological studies of feed additives (sanguinarine and saccharomyces cerevisiae) on growth performance,haematological and intestinal bacterial count with challenge test by Aeromonas hydrophila in Cyprinus carpio[J].Global Anim Sci J,2013,1(1):19-29.
[19] WANG W,DOLAN L C,VON ALVENSLEBEN S,et al.Safety of standardized Macleaya cordata extract in an eighty-four-day dietary study in dairy cows[J].J Anim Physiol Anim Nutr,2018,102(1):e61-e68.
[20] DRSATA J,ULRICHOVÁ J,WALTEROVÁ D.Sanguinarine and chelerythrine as inhibitors of aromatic amino acid decarboxylase[J].J Enzyme Inhib,1996,10(4):231-237.
[21] FRAYN K N.Non-esterified fatty acid metabolism and postprandial lipaemia[J].Atherosclerosis,1998,141(S1):S41-S46.
[22] RIVERA L,MORÓN R,ZARZUELO A,et al.Long-term resveratrol administration reduces metabolic disturbances and lowers blood pressure in obese Zucker rats[J].Biochem Pharmacol,2009,77(6):1053-1063.
[23] 丁亚南,赵月香,王玲霞,等.白藜芦醇对高脂诱导大鼠生长、血脂代谢及抗氧化力的影响[J].畜牧兽医学报,2017,48(11):2216-2224.
DING Y N,ZHAO Y X,WANG L X,et al.Effects of resveratrol on the growth,blood lipid metabolism and antioxidant capacity of rats fed with high fat diet[J].Acta Veterinaria et Zootechnica Sinica,2017,48(11):2216-2224.(in Chinese)
[24] SERGENT T,VANDERSTRAETEN J,WINAND J,et al.Phenolic compounds and plant extracts as potential natural anti-obesity substances[J].Food Chem,2012,135(1):68-73.
[25] CHO I J,AHN J Y,KIM S,et al.Resveratrol attenuates the expression of HMG-CoA reductase mRNA in hamsters[J].Biochem Biophys Res Commun,2008,367(1):190-194.
[26] GUDEV D,POPOVA-RALCHEVA S,MONEVA P,et al.Effect of supplemental Sangrovit on some biochemical indices and leukocytes phagocytic activity in growing pigs[J].Arch Zootech,2004,7:19-26.
[27] CASTILLO C,BENEDITO J L,VÁZQUEZ P,et al.Effects of supplementation with plant extract product containing carvacrol,cinnamaldehyde and capsaicin on serum metabolites and enzymes during the finishing phase of feedlot-fed bull calves[J].Anim Feed Sci Technol,2012,171(2-4):246-250.
[28] LIEN T F,HORNG Y M,YANG K H.Performance,serum characteristics,carcase traits and lipid metabolism of broilers as affected by supplement of chromium picolinate[J].Br Poult Sci,1999,40(3):357-363.
[29] LAGOUGE M,ARGMANN C,GERHART-HINES Z,et al.Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1α[J].Cell,2006,127(6):1109-1122.
[30] BAUR J A,PEARSON K J,PRICE N L,et al.Resveratrol improves health and survival of mice on a high-calorie diet[J].Nature,2006,444(7117):337-342.
[31] BRASNYÓ P,MOLNÁR G A,MOHÁS M,et al.Resveratrol improves insulin sensitivity,reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients[J].Br J Nutr,2011,106(3):383-389.
[32] MÖSTL E,PALME R.Hormones as indicators of stress[J].Domest Anim Endocrinol,2002,23(1-2):67-74.
[33] BALAJI R,WRIGHT K J,TURNER J L,et al.Circulating cortisol,tumor necrosis factor-α interleukin-1β,and interferon-γ in pigs infected with Actinobacillus pleuropneumoniae[J].J Anim Sci,2002,80(1):202-207.
[34] ETHERTON T D,BAUMAN D E.Biology of somatotropin in growth and lactation of domestic animals[J].Physiol Rev,1998,78(3):745-761.
[35] SPURLOCK M E.Regulation of metabolism and growth during immune challenge:an overview of cytokine function[J].J Anim Sci,1997,75(7):1773-1783.
[36] ZHANG L Y,QU P B,TU Y,et al.Effects of flavonoids from mulberry leaves and Candida tropicalis on performance and nutrient digestibility in calves[J].Kafkas Univ Vet Fak Derg,2017,23(3):473-479.
[37] PENNER G B,STEELE M A,ASCHENBACH J R,et al.Ruminant nutrition symposium:molecular adaptation of ruminal epithelia to highly fermentable diets[J].J Anim Sci,2011,89(4):1108-1119.
[38] TURNER J L,DRITZ S S,HIGGINS J J,et al.Effects of Ascophyllum nodosum extract on growth performance and immune function of young pigs challenged with Salmonella typhimurium[J].J Anim Sci,2002,80(7):1947-1953.
[39] 李美荃,张春勇,满意,等.博落回提取物在仔猪生产中的应用效果研究[J].家畜生态学报,2013,34(9):50-55.
LI M Q,ZHANG C Y,MAN Y,et al.Effect of Macleaya cordata extract on piglet production[J].Acta Ecologiae Animalis Domastici,2013,34(9):50-55.(in Chinese)
[40] 李会智,褚青坡,王志国,等.博落回提取物对断奶仔猪生长性能、腹泻率和血清免疫指标的影响[C]//中国猪业科技大会暨中国畜牧兽医学会2015年学术年会.厦门:中国畜牧兽医学会,2015.
LI H Z,CHU Q P,WANG Z G,et al.Effects of Macleaya cordata extract on growth performance,diarrhea rate and serum immune parameters of weaned piglets[C]//Xiamen:Chinese Animal Husbandry and Veterinary Association,2015.(in Chinese)
[41] RENCKENS R,ROELOFS J J T H,KNAPP S,et al.The acute-phase response and serum amyloid A inhibit the inflammatory response to Acinetobacter bau-mannii Pneumonia[J].J Infect Dis,2006,193(2):187-195.
[42] AKIRA S,HIRANO T,TAGA T,KISHIMOTO T.Biology of multifunctional cytokines,IL 6 and related molecules (IL 1 and TNF)[J].FASEB J,1990,4(11):2860-2867.
[43] BROUSSARD S R,ZHOU J H,VENTERS H D,et al.At the interface of environment-immune interactions:cytokine and growth-factor receptors[J].J Anim Sc,2001,79(Suppl_E):E268-E284.
[44] JUAN M E,VINARDELL M P,PLANAS J M.The daily oral administration of high doses of trans-resveratrol to rats for 28 days is not harmful[J].J Nutr,2002,132(2):257-260.
[45] 刘靖.博落回生物碱对黄羽肉鸡生长的影响[D].长沙:湖南农业大学,2010.
LIU J.The effect of macleaya alkaloids on the growth of yellow broilers[D].Changsha:Hunan Agricultural University,2010.(in Chinese)
[46] KADⅡSKA M B,GLADEN B C,BAIRD D D,et al.Biomarkers of oxidative stress study Ⅱ:are oxidation products of lipids,proteins,and DNA markers of CCl₄ poisoning?[J].Free Radic Biol Med,2005,38(6):698-710.
[47] SU J L,SHI B L,ZHANG P F,et al.Effects of yucca extract on feed efficiency,immune and antioxidative functions in broilers[J].Braz Arch Biol Technol,2016,59:e16150035.
[48] VARGA Z,CZOMPA A,KAKUK G,et al.Inhibition of the superoxide anion release and hydrogen peroxide formation in PMNLs by flavonolignans[J].Phytother Res,2001,15(7):608-612.
[49] FORMAN H J,TORRES M.Signaling by the respiratory burst in macrophages[J].IUBMB Life,2001,51(6):365-371.
[50] ZHANG C,LUO J Q,YU B,et al.Dietary resveratrol supplementation improves meat quality of finishing pigs through changing muscle fiber characteristics and antioxidative status[J].Meat Sci,2015,102:15-21.

Effect of Resveratrol and Sanguinarine on Growth Performance and Blood Biochemical Indices of 2-6 Months Old Calves

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	GUO Zijing, HE Qifu, TANG Cheng, ZHANG Bin, YUE Hua. Establishment and Application of a Real-time RT-PCR Assay for Detecting Bovine Nebovirus [J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2019, 50(4): 893-900.
[2]	GUO Zijing, HE Qifu, TANG Cheng, ZHANG Bin, YUE Hua. Establishment and Application of a Real-time RT-PCR Assay for Detecting Bovine Nebovirus [J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2019, 50(4): 893-900.
[3]	ZHANG Wei-bing, ZHANG Rong, BI Yan-liang, TU Yan, DU Han-chang, TIAN Zhong-hong, DIAO Qi-yu. Effect of Resveratrol and Sanguinarine on Growth Performance and Blood Biochemical Indices of 2-6 Months Old Calves [J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2018, 49(9): 1940-1951.
[4]	MI Si-yuan, SHI Ke-rong, ZHANG Rui-qiang, ZHANG Hai-liang, XU Qing-lei, YU Ying. RT-PCR Detection of Bovine Viral Diarrhea Virus Subtypes and Analysis of Differentially Expressed Candidate Genes in Infected Calves [J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2018, 49(7): 1432-1439.
[5]	MI Si-yuan, SHI Ke-rong, ZHANG Rui-qiang, ZHANG Hai-liang, XU Qing-lei, YU Ying. RT-PCR Detection of Bovine Viral Diarrhea Virus Subtypes and Analysis of Differentially Expressed Candidate Genes in Infected Calves [J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2018, 49(7): 1432-1439.
[6]	LI Fan, YUE Hua, QIU Wan-si, ZHANG Bin, HUANG Jian-de, TANG Cheng. Development and Application of an Insulated Isothermal PCR (iiPCR) for On-site Detecting Bovine Rotavirus [J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2017, 48(6): 1092-1098.
[7]	LI Fan, YUE Hua, QIU Wan-si, ZHANG Bin, HUANG Jian-de, TANG Cheng. Development and Application of an Insulated Isothermal PCR (iiPCR) for On-site Detecting Bovine Rotavirus [J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2017, 48(6): 1092-1098.
[8]	DING Ya-nan, ZHAO Yue-xiang, WANG Ling-xia, HAN Jin-feng, SONG Ze-he, HU Gui-li, LI Guan-ya, FAN Zhi-yong. Effects of Resveratrol on the Growth, Blood Lipid Metabolism and Antioxidant Capacity of Rats Fed with High Fat Diet [J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2017, 48(11): 2216-2224.
[9]	DING Ya-nan, ZHAO Yue-xiang, WANG Ling-xia, HAN Jin-feng, SONG Ze-he, HU Gui-li, LI Guan-ya, FAN Zhi-yong. Effects of Resveratrol on the Growth, Blood Lipid Metabolism and Antioxidant Capacity of Rats Fed with High Fat Diet [J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2017, 48(11): 2216-2224.
[10]	SHEN Liu-hong，JIANG Tao，WU Xiao-feng，JIANG Si-xun，XIAO Jin-bang，CAO Sui-zhong，YU Shu-min，DENG Jun-liang，ZUO Zhi-cai，PENG Guang-neng，MA Xiao-ping，ZHONG Zhi-jun，REN Zhi-hua，WANG Ya，HU Yan-chun. The Correlation between Adiponectin，Leptin，Visfatin in Placenta and Calf Birth Weight [J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2017, 48(1): 185-192.
[11]	SHEN Liu-hong，JIANG Tao，WU Xiao-feng，JIANG Si-xun，XIAO Jin-bang，CAO Sui-zhong，YU Shu-min，DENG Jun-liang，ZUO Zhi-cai，PENG Guang-neng，MA Xiao-ping，ZHONG Zhi-jun，REN Zhi-hua，WANG Ya，HU Yan-chun. The Correlation between Adiponectin，Leptin，Visfatin in Placenta and Calf Birth Weight [J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2017, 48(1): 185-192.
[12]	HUANG Kai-wu，TU Yan，SI Bing-wen，XU Gui-shan，DU Hong-fang，DIAO Qi-yu. Effect of Protein with Different Sources in Milk Replacer on Energy，Nitrogen Metabolism and Immune State of Suckling Calf [J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2016, 47(9): 1868-1878.
[13]	HUANG Kai-wu，TU Yan，SI Bing-wen，XU Gui-shan，DU Hong-fang，DIAO Qi-yu. Effect of Protein with Different Sources in Milk Replacer on Energy，Nitrogen Metabolism and Immune State of Suckling Calf [J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2016, 47(9): 1868-1878.
[14]	LI He-qiong，LIU Qiang，WANG Cong，ZHANG Yan-li，PEI Cai-xia，WANG Yong-xin，GUO Gang，HUO Wen-jie，ZHANG Shuan-lin，LIU Jian-xin. Effects of 2-methylbutyrate Supplementation on Rumen Fermentation，Enzyme Activities and Cellulolytic Bacteria in Pre- and Post-weaning Dairy Calves [J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2015, 46(12): 2218-2226.
[15]	LI He-qiong，LIU Qiang，WANG Cong，ZHANG Yan-li，PEI Cai-xia，WANG Yong-xin，GUO Gang，HUO Wen-jie，ZHANG Shuan-lin，LIU Jian-xin. Effects of 2-methylbutyrate Supplementation on Rumen Fermentation，Enzyme Activities and Cellulolytic Bacteria in Pre- and Post-weaning Dairy Calves [J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2015, 46(12): 2218-2226.