犬乳腺肿瘤中MUC1的表达及临床意义

doi:10.11843/j.issn.0366-6964.2018.07.021

Abstract

Abstract:

This study was conducted to assess the influences of MUC1 in cancer invasion, metastasis, classification and grade in mammary tumors. This work was designed to investigate the expression of MUC1 mRNA and MUC1 in canine mammary tissues. Forty-seven canine mammary gland tumors(20 benign and 27 malignant mammary tumors) and mammary gland tissues from 3 healthy dogs were investigated for MUC1 mRNA and MUC1 by Real-Time PCR and immunohistochemistry(IHC), respectively. The results showed that the expression levels of MUC1 gene and MUC1 in canine mammary tumors were significant higher than that in healthy mammary gland(P<0.05), and a significant correlation was observed between the expression levels of MUC1 gene and MUC1 and malignance grades. In conclusion, the expression levels of MUC1 gene and MUC1 may become new and valuable biomarkers for diagnosis and malignance grade in canine mammary tumors.

Key words: MUC1, canine mammary tumors, real-time PCR, immunohistochemistry

CLC Number:

S857.26

DIAO Hong-xiu, LI Yi, LIN De-gui, ZHANG Di. Expression of MUC1 and Its Clinical Value in Canine Mammary Tumors[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2018, 49(7): 1511-1516.

References

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Expression of MUC1 and Its Clinical Value in Canine Mammary Tumors

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