ACTA VETERINARIA ET ZOOTECHNICA SINICA ›› 2018, Vol. 49 ›› Issue (5): 871-878.doi: 10.11843/j.issn.0366-6964.2018.05.001

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Research Progress on Genomic Copy Number Variations in Cattle

PEI Sheng-wei1,2, WANG Li1,2, CAO Xue-tao1,2, LI Wan-hong1,2, LI Fa-di1,2,3, YUE Xiang-peng1,2*   

  1. 1. State Key Laboratory of Grassland Agro-ecosystems, College of Pastoral Agriculture Science and Technology, Lanzhou University, Lanzhou 730020, China;
    2. Key Laboratory of Grassland Livestock Industry Innovation of Ministry of Agriculture, Lanzhou 730020, China;
    3. Sheep Breeding Biotechnology Engineering Laboratory of Gansu Province, Minqin 733300, China
  • Received:2017-10-27 Online:2018-05-23 Published:2018-05-23

Abstract:

Copy number variation (CNV), as an important component of genomic structural variation (SV), plays important roles in phenotypic variability, disease susceptibility estimates and species evolution. Currently, a large number of studies have been widely conducted to analyze genome-wide CNV of domestic animals using high throughput and density technologies, which enable CNV as an important molecular marker for complex traits in genome-wide association analysis study (GWAS). In addition, CNV provides a new insight into the analysis of population genetic structure. Therefore, this review comprehensively summarized definition, formation mechanism, distribution characteristics, analyzing methods, genetic effect of CNV in cattle and the CNV on bovine Y chromosome based on previous studies. Meanwhile, we also raised some problems in current CNV studies, and provide a brief outlook of the future for CNV studies, which would supply guidance for cattle genome CNV studies in the future.

Key words: cattle, copy number variation, genetic effect

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