ACTA VETERINARIA ET ZOOTECHNICA SINICA ›› 2018, Vol. 49 ›› Issue (5): 879-886.doi: 10.11843/j.issn.0366-6964.2018.05.002

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The Role of Macrophage-γδ T Cell Immune Axis in the Pathogenesis of Glässer's Disease

CHENG Lei1, CHEN Hong-bo2*   

  1. 1. Institute of Animal Husbandry and Veterinary, Wuhan Academy of Agricultural Science and Technology, Wuhan 430208, China;
    2. School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, Wuhan 430023, China
  • Received:2017-08-24 Online:2018-05-23 Published:2018-05-23

Abstract:

Haemophilus parasuis (Hps) is a major bacterial pathogen in pigs that is prevalent in many countries worldwide. It can easily parasitize the upper respiratory tract of newborn piglets through contact transmission. Under certain conditions, Hps infection leads to systematic inflammations, in which the most typical clinical symptom is the so-called Glässer's disease. Co-infections of Hps with other bacteria and/or viruses have been reported, which can impair the host protective immunity and affect the production efficiency seriously. In the last decade, Hps infection has continuously attracted scientists and great progress in the basic research fields of prevention, control, and in vivo/in vitro challenges have been made. Whereas the molecular mechanism of Hps and host interaction is still fuzzy that warrants further investigation. Based on our studies and results from other teams, we speculate that the "Macrophage (MΦ)-γδT cell" immune axis may play a crucial role in the pathogenesis of Glässer's disease. In order to discuss better with our academic faculties, we herein present a deep review on this hypotheses. Objectives of this article are to discuss key issues of host immune response and to discover the underlying main cellular players. We hope to provide insight for the signaling pathway studies and Hps resistant genetic marker discoveries in pigs.

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