类视黄醇X受体基因调控动物季节性发情和发情周期的研究进展

doi:10.11843/j.issn.0366-6964.2019.08.001

畜牧兽医学报 ›› 2019, Vol. 50 ›› Issue (8): 1525-1535.doi: 10.11843/j.issn.0366-6964.2019.08.001

类视黄醇X受体基因调控动物季节性发情和发情周期的研究进展

李华振^1,2, 狄冉¹, 刘秋月¹, 胡文萍¹, 王翔宇¹, 马琳¹, 刘武军^2*, 储明星^1*

1. 中国农业科学院北京畜牧兽医研究所, 农业部动物遗传育种与繁殖重点实验室, 北京 100193;
2. 新疆农业大学动物科学学院, 乌鲁木齐 830052

收稿日期:2019-01-18 出版日期:2019-08-23 发布日期:2019-08-19
通讯作者: 储明星,主要从事羊优异繁殖性状分子机理研究,E-mail:mxchu@263.net;刘武军,主要从事分子遗传学、反刍动物生产,E-mail:lwj_ws@sohu.com
作者简介:李华振(1992-),男,新疆玛纳斯人,硕士生,主要从事绵羊分子育种研究,E-mail:1078728382@qq.com;狄冉(1979-),女,山东泰安人,博士,副研究员,主要从事羊优异繁殖性状分子机理研究,E-mail:dirangirl@163.com。李华振和狄冉为同等贡献作者
基金资助:
国家自然科学基金（31572371）；国家肉羊产业技术体系专项（CARS-38）；中国农业科学院科技创新工程（ASTIP-IAS13）；农业科研杰出人才及其创新团队项目（农办人[2015]62号）；国家万人计划科技创新领军人才项目（W02020274）；天津市农业科技成果转化与推广项目（201704020）

Research Progress on the Regulative Role of Retinoid X Receptors Gene in Animal Seasonal Estrus and Estrous Cycle

LI Huazhen^1,2, DI Ran¹, LIU Qiuyue¹, HU Wenping¹, WANG Xiangyu¹, MA Lin¹, LIU Wujun^2*, CHU Mingxing^1*

1. Key Laboratory of Animal Genetics, Breeding and Reproduction of Ministry of Agriculture, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China;
2. College of Animal Science, Xinjiang Agricultural University, Urumqi 830052, China

Received:2019-01-18 Online:2019-08-23 Published:2019-08-19

摘要/Abstract

摘要： 类视黄醇X受体（retinoid X receptors，RXRs）属于配体依赖性核受体家族成员。以往的许多研究揭示了RXRs在季节性发情和发情周期中的重要性，但由于RXRs必须与自身或者其他核受体形成二聚体才能发挥作用，且每种二聚体发挥的作用不同，使其在繁殖中的分子机制研究变成了难题。前人研究表明，RXRs在季节性发情动物下丘脑-垂体-性腺（HPG）轴组织中有不同水平的表达，THRs/RXRs、RARs/RXRs和PPARs/RXRs等二聚体能刺激下丘脑GnRH的释放达到调控季节性发情作用，同时参与调节卵巢颗粒细胞的增殖、卵巢血管组织重塑和类固醇生成从而影响动物发情周期中时期转换。本文总结了目前关于RXRs及其二聚体在动物季节性发情和发情周期不同繁殖活动中的作用，以期为后续研究提供参考依据。

关键词: RXRs, 二聚体, 下丘脑-垂体-性腺轴, 季节性发情, 基因表达

Abstract: Retinoid X receptors (RXRs) are members of the ligand-dependent nuclear receptor family. Many studies in the past have revealed the importance of RXRs in animal's seasonal estrus and estrous cycles, but RXRs must form dimers with themselves or other nuclear receptors to work. Different dimers play different roles, therefore their molecular mechanism of playing role in reproduction is difficult to study. Some studies have shown that RXRs expressed at different levels in the hypothalamic-pituitary-gonadal (HPG) axis tissues of seasonal estrus animals. Dimers of THRs/RXRs, RARs/RXRs and PPARs/RXRs can stimulate the release of GnRH in the hypothalamus to regulate seasonal estrus and proliferation of ovarian granulosa cells, remodeling of ovarian vascular tissue, and steroid production, which affect the animal estrous cycle conversion. This paper summarizes the role of RXRs and their dimers in the different reproductive activities related to seasonal estrus and estrous cycle of animals, and provides a reference for future research.

Key words: RXRs, dimer, HPG axis, seasonal estrus, gene expression

中图分类号:

S814.1

李华振, 狄冉, 刘秋月, 胡文萍, 王翔宇, 马琳, 刘武军, 储明星. 类视黄醇X受体基因调控动物季节性发情和发情周期的研究进展[J]. 畜牧兽医学报, 2019, 50(8): 1525-1535.

LI Huazhen, DI Ran, LIU Qiuyue, HU Wenping, WANG Xiangyu, MA Lin, LIU Wujun, CHU Mingxing. Research Progress on the Regulative Role of Retinoid X Receptors Gene in Animal Seasonal Estrus and Estrous Cycle[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2019, 50(8): 1525-1535.

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类视黄醇X受体基因调控动物季节性发情和发情周期的研究进展

Research Progress on the Regulative Role of Retinoid X Receptors Gene in Animal Seasonal Estrus and Estrous Cycle

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