畜牧兽医学报 ›› 2018, Vol. 49 ›› Issue (10): 2092-2101.doi: 10.11843/j.issn.0366-6964.2018.10.005

• 综述 • 上一篇    下一篇

猪舍颗粒物对肺泡巨噬细胞功能的影响

唐倩, 戴鹏远, 吴胜, 沈丹, 李延森, 李春梅*   

  1. 南京农业大学动物科技学院, 南京 210095
  • 收稿日期:2018-02-27 出版日期:2018-10-23 发布日期:2018-10-23
  • 通讯作者: 李春梅(1974-),女,教授,博士生导师,主要从事动物环境生理与营养研究,Tel:025-84395971,Fax:025-84395971,E-mail:chunmeili@njau.edu.cn
  • 作者简介:唐倩(1991-),女,江苏泰州人,博士生,主要从事畜禽环境生理学研究,E-mail:2016205021@njau.edu.cn
  • 基金资助:

    国家重点研发计划项目(2016YFD0500505);国家自然科学基金(31772648);2018年江苏省研究生科研创新计划

Effects of Particulate Matter from Pig House on Alveolar Macrophage

TANG Qian, DAI Peng-yuan, WU Sheng, SHEN Dan, LI Yan-sen, LI Chun-mei*   

  1. College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China
  • Received:2018-02-27 Online:2018-10-23 Published:2018-10-23

摘要:

猪舍空气环境颗粒物与猪的健康和生产密切相关,是猪呼吸道疾病发生的重要原因之一。猪舍内颗粒物携带内毒素、重金属、致病菌等多种有毒有害物质,成分复杂,毒性大,可诱发肺部炎症反应,但具体机制尚不十分清楚。肺泡巨噬细胞作为肺中的游离免疫细胞,在吞噬和清除颗粒物的过程中发挥着重要作用。本文从猪舍颗粒物的特征及成分入手,综述了颗粒物对猪的生长性能和呼吸道健康影响,并着重阐述了颗粒物对肺泡巨噬细胞功能的影响及其调控机制。颗粒物可通过降低肺泡巨噬细胞吞噬能力、改变细胞极性以及激活TLR4-NF-κB/AP-1信号通路,影响肺泡巨噬细胞的先天免疫,其亦可作为抗原呈递细胞引发适应性免疫反应。本文可为今后对猪舍内颗粒物的深入研究提供参考依据。

Abstract:

Particulate matter (PM) from pig houses is closely related to pig's health status and production performance and it is one of the important reasons for causing respiratory diseases in pigs. PM from pig houses carry many toxic and harmful substances, such as endotoxin, heavy metals, pathogenic bacteria and so on, thus the PM is more complex and toxic. PM can induce inflammatory response in lung, but the exact mechanism is still unclear. Alveolar macrophage, a kind of free immune cells in lung, play a major role in clearing and processing PM. Firstly, the characteristics and components of PM were put forward. Then the effect of PM on growth performance and respiratory health of pigs was described. Lastly, the effect of PM on alveolar macrophage function and its regulatory mechanisms was focused on. PM can influence the innate immunity of alveolar macrophage by reducing its phagocytic capacity, altering cell polarization and activating TLR4-NF-κB/AP-1 signaling pathway, and it can also function as antigen-presenting cells to initiate adaptive immune responses. In summary, this review provide the theoretical basis for studying PM from pig houses.

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